A Rare Case of Thrombocytosis with Duble Malignant Etiology – Pathogenetic Interrelationships and Consequences
Journal Title: Scholars Journal of Medical Case Reports - Year 2015, Vol 3, Issue 8
Abstract
Abstract: The etiological diagnosis of each thrombocytosis is a challenge for practitioners. There are situations where essential thrombocythemia is associated since the diagnosis, but sometimes also subsequently, with thrombocytosis evolving conditions. On the other hand, reactive thrombocytosis can be accompanied by essential thrombocythemia. We present the case of a patient who at diagnosis had colon cancer and essential thrombocythemia. Although essential thrombocythemia was treated according to guidelines, colon cancer relapsed and its evolution was unfavorable. The mechanisms that may explain the association of the two malignant proliferation and by which essential thrombocythemia may contribute to relapse and unfavorable evolution of colon cancer are discussed. Keywords: Colon cancer, Essential thrombocythemia, Genomic instability, Hydroxycarbamide, Interferon, JAK2V617F, Second cancer, Statin, Thrombocytosis, Thrombosis.
Authors and Affiliations
Mihăilă RG, Marchian S
Keywords
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