A Rare Case Report on IgG4 Related Diseases
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
IgG4-related disease (IgG4-RD) is a newly recognized disorder, characterized by massive IgG4+ lymphocyte and plasma cell infiltration, storiform fibrosis, causing enlargement, nodules or thickening of the various organs, simultaneously or metachronously [1–4]. .The present case report describes the clinical case of a 62 year male with complaint of fever, jaundice, abdominal pain & loss of weight since 1 month. CECT Whole Abdomen shows hepatospleenomegaly,subdiaphragmatic and abdominal lymphadenopathy .Exploratory laparotomy done & abdominal lymph nodes sent for histopathology shows features of Florid follicular lymphoid hyperplasia with infilteration by plasma cells in interfollicular area. Causes of increased plasma cells in lymph node were to be ruled out therefore IHC of abdominal lymph node was done which depicted reactive lymphoid hyperplasia with increased IgG4 positive plasma cells(>50/hpf) along with increase plasma cell in interfollicular area that are polytypic for kappa/ lambda leading to diagnosis of IgG4 RD and treatment of corticosteroid was started.The diagnosis of IgG4-RD was based on a combination of features that include clinical parameters, imaging and histopathology, immunohistochemistry .
Authors and Affiliations
Dr Deepika Wadhera, Dr Ramesh Kumar Kundal, Dr Mohanvir Kaur, Dr Najinder Preet Kaur, Dr Arshiya Bansal
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