A Retrospective Analytical Study on Drug Induced Stevens Johnson Syndrome and Toxic Epidermal Necrolysis in a Tertiary Care Hospital in Telangana.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Objective: To assess the relationship between age, sex of the patient, and seasons of the year with StevensJohnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) and to find out common causative drugs and clinical outcome of SJS and TEN cases reported from Osmania Medical College. Materials and methods: A retrospective analytical study done on drug induced SJS and TEN using the data collected from the individual case safety reports (ICSRs) reported from Adverse drug reaction Monitoring Center (AMC), Osmania Medical College (OMC) to National Co-ordination Center, Pharmacovigilance Program of India (NCC, PvPI) from January 2015 to March 2017. UMC-WHO causality assessment scale was uses to assess the causality. Results: Total 24 cases of drug induced SJS and TEN were reported over a period of 26 months. 62% were male and 38% were female. Patient’s age ranges from 3years to 71 years. Antiepileptics and antibiotics were suspected to be common causative drugs for SJS and TEN. More cases of antibiotic induced SJS were reported during winter. Causality assessment was certain in 2 cases and probable in 22 cases. SJS and TEN is a serious ADR associated with 8% mortality in this study. Discussion: In this study we observed male predominance and more cases were reported during winter. Antiepileptics and antibiotics were the common suspected drugs for SJS and TEN. It is a serious ADR associated with fatal out come in elderly patients.
Authors and Affiliations
Dr. A. B Suguna, Dr. T. Chakradhar, Miss. Sravani M
Keywords
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- EP ID EP243553
- DOI 10.9790/0853-1610043336
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