A RETROSPECTIVE PREVALENCE STUDY OF DRUG INDUCED NEPHRITIS- A HOSPITAL BASED CROSS SECTIONAL STUDY IN CENTRAL INDIAN POPULATION
Journal Title: International Journal of Medical Science and Diagnosis Research (IJMSDR) - Year 2018, Vol 2, Issue 6
Abstract
Background: Drug-induced kidney disease constitutes an important cause of acute renal failure and chronic kidney disease in present day clinical practice. Different classes of drugs, by virtue of immunological mechanisms or direct toxicity initiate certain stereotyped renal responses. Objectives: To estimate the incidence and prevalence of drug induced nephrotoxicity, a retrospective study was conducted in the Department of Medicine, Sri Shankaracharya Institute of Medical Sciences, Bhilai, Chhattisgarh, over a period of 6 months from January 2018 to June 2018. The study included 120 determinations of drug induced nephritis between 30-70 years age group. 49.5% of patients were female. Methods: screening of 500 people aged 30 and above was carried out. Demographic and anthropometric data were obtained, urine was analyzed for protein by dipstick and serum creatinine was measured in all participants. Glomerular filtration rate was estimated (eGFR) using the 4-variable modification of diet in renal disease (MDRD) equation and Cockcroft-Gault equation corrected to the body surface area (CG-BSA). Results: proteinuria was 2.8%. DIN was seen in 120(6.3%) subjects when GFR was estimated by MDRD equation. The prevalence of DIN was 24% by the CG-BSA method. There was a statistically significant relationship of DIN with gender, advancing age, abdominal obesity, smoking, presence of diabetes and hypertension. The wide difference between the DIN prevalence between MDRD and CG-BSA equations suggests the need for a better measure of kidney function applicable to Indian population. CG-BSA equations suggests the need for a better measure of kidney function applicable to Indian population. Keywords: Body mass index (BMI), Cockcroft-Gault (CG), Chronic kidney disease (CKD), drug induced nephrotoxicity (DIN), Proteinuria, Glomerular filtration rate (GFR)
Authors and Affiliations
Dr. Shivnath Nandan1
Keywords
Related Articles
- EP ID EP531903
- DOI -
- Views 59
- Downloads 0
RELATIONSHIP OF CD4 COUNT WITH FNAC FINDINGS OF LYMPH NODE IN HIV PATIENTS WITH LYMPHADENOPATHY
As the HIV virus primarily infects the lymphocytes, lymph nodes are commonly involved during all stages of infection and are one of the earliest signs in HIV infected patients. The most common conditions affecting the ly...
TO EVALUATE THE ASSOCIATION OF ANTHROPOMETRIC INDEX (BODY MASS INDEX AND WAIST-CIRCUMFERENCE) IN PATIENTS WITH NON ALCOHOLIC FATTY LIVER DISEASE
Background: The present study entitled To Evaluate the Association of Anthropometric Index (body mass index and waist-circumference) in patients with non-alcoholic Fatty Liver Disease" was conducted in the Departmen...
ENDOSCOPIC SCREENING OF GASTROESOPHAGEAL CANCER IN PATIENTS WITH IDIOPATHIC DEEP VENOUS THROMBOSIS
Deep vein thrombosis (DVT) is a common manifestation in patients with cancer and may appear as the first manifestation of the disease. The aim of this study was to evaluate the prevalence of tumors of the esophagus, stom...
Phobia and its Homoeopathic Treatment
A phobia is an irrational fear, a kind of anxiety disorder in which the individual has a relentless dread of a situation, living creature, place, or thing. If confronted with the source of their phobia, the person will s...
EFFECTS OF PHYSIOTHERAPY ON BREAST CANCER RELATED SECONDARY LYMPHEDEMA: A SYSTEMATIC REVIEW.
Purpose: The aim of this systematic review is to assess the effect of Physiotherapy Rehabilitation on breast cancer-related lymphedema (BCRL) in order to elucidate the role of Physiotherapy in these patients. Methods: A...