A RETROSPECTIVE STUDY OF CLINICAL AND HISTOPATHOLOGICAL SPECTRUM OF IMMUNOBULLOUS DISORDERS AT A TERTIARY CARE CENTRE IN WESTERN INDIA.
Journal Title: PARIPEX-Indian Journal of Research - Year 2017, Vol 6, Issue 7
Abstract
Background: Immunobullous disorders are characterized by antibody-mediated bullous lesions affecting the skin and mucosa. Aims: To study clinical presentation and histopathological pattern of different immunobullous disorders. Methods: A retrospective study of 150 cases of immunobullous disorders were studied over a span of two years. Detailed clinical examination and investigations were carried out. Results: Among the cases studied, 102 cases (68%) belonged to pemphigus vulgaris. Clinical diagnosis & histopathological findings were consistent in 97.33% (146/150) cases. Among cases presented with itching, 66.95% cases had either eosinophil or neutrophil infiltrate in dermis as a finding in histopathological section and 53.04% had similar infiltrate in blister cavity. Conclusion: It is imperative that the clinical differential diagnosis can be correlated with the gross and microscopic observations in order to render a clinically meaningful diagnosis and further management of the patients.
Authors and Affiliations
Dr. Sneharani H. Chandak, Dr. Bharti K. Patel, Dr. Neela V. Bhuptani
Keywords
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