A retrospective study of clinical and laboratory parameter of acute leukaemia’s
Journal Title: MedPulse -International Medical Journal - Year 2016, Vol 3, Issue 5
Abstract
Aim: To evaluate clinical and heamatological profile of patients with leukemia admitted to Goverment. Rajaji Hospital, Madurai. Materials and Methods: The present study is a retrospective study carried out in the Department of Pathology, Madurai Medical College for the period of 2 years. All patients with acute leukemia who were admitted in the departments of Pediatrics, Medicine and Medical Oncology at Govt. Rajaji Hospital were included in the study. The clinical and lab profiles were evaluated and were classified into AML / ALL using FAB classification. The results of 121 patients are presented in the study. A thorough history concentrating on specific epidemiologic pattern, family history, environmental and previous chemotherapy were noted, physical examination, lab investigation results such as HB,TC, Ultrasound abdomen, Peripheral Smear and Bone marrow aspiration were analyzed. Result and Discussion: In the present study the incidence of leukemia in Madurai 0.45 % which is comparable with Indian studies, quoting an incidents of 0.34 % to 1 %. The most common type of acute leukemia is ALL 62.8 % followed by AML 36.4 %. In the present study AML-M2 is most common 59.1 % of AML cases followed M4 18.2 %. ALL L1 and L2 have equal incident among ALL cases. The most common type of childwood leukemia is ALL 79.6 % followed by AML 16.6 %. The most common presenting symptom is fever. Generalized lymphadenopathy is present in 36 % of cases of ALL, hyperleukocysis was present in 8.3 % of cases. 78.4 % of cases were associated with thromphocytopenia, Subleukemic presentation was present in 14.2 % cases. 64.2 % of cases showed more than 90 % of blast in bone marrow. The percentage of blast in bonemarrow was higher in ALL cases.
Authors and Affiliations
M Sintha
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