A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience
Journal Title: Türkderm - Deri Hastalıkları ve Frengi Arşivi - Year 2019, Vol 18, Issue 4
Abstract
Objective: Patients with recurrent metastatic germ cell tumor (GCT) can be treated with second-line or even third-line regimens; 20-30% of testicular GCT (TGCT) relapse or become refractory after first-line therapy and optimal treatment for this group is not very well defined. Materials and Methods: We presented the analysis of the efficacy of high-dose chemotherapy and peripheral-blood stem-cell transplantation in patients treated between 2016 and 2019. Five patients with five autologous stem-cell transplantations (ASCT) were analyzed retrospectively. All patients were treated with bleomycin, etoposide, cisplatin as first-line therapy and paclitaxel, ifosfamide, cisplatin was given as salvage chemotherapy. Stem–cell collection was performed with granulocyte stimulating factor. ASCT was performed with carboplatin (700 mg/m2) and etoposide (750 mg/m2). The results were provided as median (min-max). Results: After ASCT, all patients were in complete remission (CR). The follow-up after ASCT was 12 months. At the 12-month follow-up, four patients were still alive and in CR, and only one patient died at 6th month after ASCT due to recurrence. Grade 2/4 toxicities were observed in five patients. Only one patient died due to complications of transplantation. Conclusion: Although the number of the patients in this study was limited, ASCT seemed to be a safe and effective treatment modality in recurrent refractory non-seminomatous TGCT, and treatment-related mortality was very low in this heavily pretreated group.
Authors and Affiliations
Şebnem İzmir Güner, Ekrem Güner
Keywords
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- EP ID EP665783
- DOI 10.4274/uob.galenos.2019.1284
- Views 95
- Downloads 0
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