A Review and Acute Oral Toxicity Study of Asystasia variabilis Trim- A Medicinal Plant used by Folklore Practitioners
Journal Title: International Journal of Ayurveda and Pharmaceutical Chemistry - Year 2018, Vol 0, Issue 0
Abstract
Introduction: Ayurveda believes every plant is medicinal. Asystasia variabilis Trim. belonging to the family Acanthaceae, called as Maithaalakaddi by folklore practitioners of Udupi. It is a semi scandent herb, generously growing in rainy season throughout coastal region, which is used effectively by the Folklore practitioners to treat different pitta vikaras. Considering its therapeutic potentialities the drug is reviewed and to establish its safety profile the Acute Oral Toxicity study is carried out. Methodology: The literary review was carried out by collecting the relevant material from Vedas, Samhitas and Nighantus. Information about the drug in recent day is reviewed from relevant textbooks, journals and relevant websites. The whole matured plant of A. variabilis was identified, collected to prepare churna (powder) and AOT study was carried out as per OECD-425 guidelines. Results: Although, various therapeutic applications are mentioned in detail in various ethno-medico-botanical surveys which are published, the drug is not considered as a source for any of the drug mentioned in Samhita or Nighantus. The acute oral toxicity study shows (LD50) is much more than 2000mg/kg. Conclusion: The plant is considered as new to Ayurveda and it is proved it to be a safe drug.
Authors and Affiliations
Kavitha . , Padigar Shrikanth
Keywords
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