A Review Article on Etiopathogenesis of Osmf
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Areca nut chewing is a great hazard and related to oral mucosa lesion in large population worldwide. In India pan masala, gutkha and mawa chewing is quite prevalent. In some sections of society, quid chewing is even part of the social culture. Areca nut which is most commonly associated with development of OSMF contains various alkaloids which interfere with molecular process of deposition and/or degradation of extracellular matrix molecule such as collagen causing imbalance in normal process. The various pathological effects of these alkaloids are: 1.Reduced phagocytosis of collagen by fibroblast. 2. Up and down regulation of copper dependent enzyme lysyl oxidase, matrix metallo proteinase and tissue inhibition of matrix metallo proteinase . 3.Increased levels of cytokines in lamina propria. Various studies done in past put OSMF as premalignant disorder (PMDs). Understanding the etiopathology of OSMF may help to revert the risk factors so as to minimize the chance of development of disease which is incorporated in primordial prevention of disease.
Authors and Affiliations
Dr. Veenita Singh, Dr. Mohit Srivastava, Dr. Rajesh Roshan, Dr. Harsimrat Dhingra, Dr. Tushar Goel, Dr. Rahul Mishra
Keywords
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- EP ID EP595829
- DOI 10.9790/0853-1604105860.
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