A REVIEW: DIPEPTIDYLPEPTIDASE-4 INHIBITORS (GLIPTINS)
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 12
Abstract
Dipeptidyl peptidase-4 inhibitors (DPP-4s), also commonly called gliptins. The need of the hour is a refreshing class of drugs whose effects on hyperglycemia can be sustained, without adversely affecting the survival of beta-cells and are weight neutral and free of hypoglycaemia, a true class of anti-hyperglycemics, a dream too good to be true. Classification of gliptins involve 1. Peptidomimetics: Which mimic the DPP-4 enzyme E.g.-vildagliptin and saxagliptin 2. Non-Peptidomimetics-Which those that do not mimic DPP4 enzyme. E.g. Sitagliptin, Alogliptin, Linagliptin. SAR (Structural Activity Relationship), pharmacology, mechanism of action of drugs of gliptin classes are explain in th following review.
Authors and Affiliations
Anjum I. Patel
Keywords
Related Articles
- EP ID EP674733
- DOI -
- Views 161
- Downloads 0
DENTAL CARIES AND NUTRITION AMONG PREGNANT WOMEN IN SABIYA REGION, KINGDOM OF SAUDI ARABIA- 2017 RESEARCHER
To measure dental caries and nutrition among pregnant women in Sabya Region, 2017. Methods: A descriptive analytical study was designed to collect data from pregnant women visiting a PHC in sabya region, Saudi Arabia fro...
A REVIEW ON “NEW GENERATION EXCIPIENTS OF MULTIFUNCTIONAL NOVAL DOSAGE FORM”
In a Present Study of Pharmacy Co-processing is the way that new excipients approaching to the market without undergoing accurate safety testing of completely new chemical. It can be defined as combining two or more esta...
A REVIEW ON TREATMENT OF RENAL ANEMIA IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND HEMODIALYSIS
Anemia is one of the most common and morbid complications of chronic kidney disease, causing unpleasant symptoms and reducing the quality of life. It is a very common complication of CKD and result in the interference of...
CIPROFLOXACIN ANTIBIOTIC RESISTANCE IN ACUTE RESPIRATORY INFECTION (ARI): IDENTIFICATION OF BACTERIA IN PATIENT CLINICAL ISOLATES AT TASIKMALAYA CITY HEALTH CENTER, INDONESIA
Objective: Ciprofloxacin is an antibiotic for the treatment of several bacterial infections, and is used as the drug of choice in the treatment of Acute Respiratory Infection (ARI). Previous studies have shown that resis...
THE EFFECT OF METHIDATHION ON SEX HORMONES, SPERM PARAMETERS AND TESTICULAR TISSUE IN MICE
The present study aimed to identify the effect of methidathion on sex hormones, sperm parameters and testicular tissue in mice Mus musculus. Adult male mice divided into three groups (8 for each group), the first group i...