A Review of Procedures Involved in Human Umbilical Cord Blood Banking and Transplantation
Journal Title: Iranian Journal of Blood and Cancer - Year 2014, Vol 7, Issue 1
Abstract
Cord blood hematopoietic stem cells are widely used as an alternative source for hematopoietic stem cells transplant. Increasing rate of patients who need hematopoietic stem cells transplant and many advantages of cord blood in comparison to bone marrow hematopoietic stem cells, have promoted banking of cord blood units. Cord blood banking requires accurate steps in donor selection, cord blood collection, processing, cryopreservation and finally screening and testing of the units. The main limitation of umbilical cord blood transplantation is cell dose and resolving this limitation is vital in avoiding frequent problems in hematopoietic stem cells transplant. Transplantation of more than one unit and ex vivo expansion of umbilical cord blood units, decrease these limitation. Furthermore, the international standard guidelines have been published by the Foundation for the Accreditation of Cellular Therapy (FACT)-NetCord to improve the quality of units and simulation of cord blood banks activities. This review presents a general overview on cord blood banking and related activities and its improvement during last two decades. Keywords: Blood banking, cord blood, hematopoietic stem cells.
Authors and Affiliations
M. Nikougoftar Zarif
Keywords
Related Articles
- EP ID EP363261
- DOI -
- Views 77
- Downloads 0
Frequency of Blood Components Wastage and Associated Factors in Yazd Healthcare Centers
Background: Excessive ordering of blood components imposes heavy costs to blood transfusion centers and increases the amount of blood product wastage due to lack of their use. In recent years, attempts have been made aga...
The Difference in Initial Leukocyte Count, Bone Marrow Blast Cell Count and CD 34 Expression in Patients with Acute Myeloid Leukemia with and without NPM1 gene Mutation
Background: Mutation in NPM1 gene has been reported to be the most common genetic mutation in de novo acute myeloid leukemia (AML). AML with NPM1 gene mutation usually presents with higher initial leukocyte and blast cel...
Frequency of Torque Teno Mini Virus in Hepatitis B and C Patients and Healthy Blood Donors in Isfahan, Iran
Background: Recently, some new viruses have been identified for their association with hepatitis which Torque Teno Mini Virus being among them. The aim of this study was to determine the frequency of Torque Teno Mini Vir...
Fungal Infections in Pediatric Patients with Hematologic Malignancies
As the data on the epidemiology and outcome of fungal infections in children with hematologic cancer are limited especially in Iran, this study was aimed to delineate the epidemiologic features and outcome of fungal infe...
Clinical application of plasma derived medicines: current situation and future trend
This article has no abstract.