A Review of the Role of Mitochondrial Manganese Superoxide Dismutase in Human Disorders, such as, Diabetes
Journal Title: Journal of Endocrinology and Diabetes - Year 2016, Vol 3, Issue 3
Abstract
A review of the antioxidant gene manganese Superoxide Dismutase (SOD-2) and its association with disease processes, especially Diabetes Mellitus (DM) and diabetic complications. The endogenous antioxidant enzyme systems, such as observed with Superoxide Dismutase (SOD), helps to manage the levels of Reactive Oxygen Species (ROS) in a cell that are generated by the cell's respiratory reactions. The role of free radical reactions in protein oxidation, DNA damage and lipid peroxidation is strongly debated in relation to human disease and has been implicated in many disease states.
Authors and Affiliations
Annwyne Houldsworth
Keywords
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- EP ID EP333671
- DOI 10.15226/2374-6890/3/3/00151
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