A REVIEW ON CHIKUNGUNYA VIRUS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
Mosquitoes transmit numerous arboviruses including dengue and chikungunya virus (CHIKV). Chikungunya is a re-emerging arthropod-borne viral disease caused by Chikungunya virus (CHIKV) belonging to the Togaviridae family of genus Alphavirus. It is a virus with a single stranded, positive sense RNA, as its genome. It is maintained in a sylvatic and urban cycle involving humans and the mosquito species Aedes aegypti and Aedes albopictus. It has a major health impact on humans as it causes fever, rashes, arthralgia and myalgia. Polyarthralgia is the most important feature of CHIKV infection which primarily affects the small joints of the wrists and fingers along with the large joints like shoulders and knees. Currently, there are no vaccines or treatment regimens available for CHIKV infection. The molecular mechanism underlying the chronic polyarthralgia observed in patients is not well understood. The abundance of bacteria from the Enterobacteriaceae family increased with CHIKV infection whereas the abundance of known insect endosymbionts like Wolbachia and Blattabacterium decreased. In this review we have summarized the CHIKV organization, replication, epidemiology, clinical manifestations and pathogenesis with emphasis on the arthralgia.
Authors and Affiliations
Birendra Kumar , Vishwabhan Singh , Uttam Joon , Vishal Suvagiya
Keywords
Related Articles
- EP ID EP140300
- DOI -
- Views 92
- Downloads 0
PHYSICOCHEMICAL ANALYSIS OF WATER OF BAGALKOT DISTRICT, KARNATAKA IN INDIA
Physicochemical analysis such as temperature, pH, Total hardness, Chloride, fluoride, iron, Total Alkalinity, Nitrate, Nitrite and sulfate of bore wells, drinking water has been carried out from twenty sampling stations...
PRELIMINARY PHYTOCHEMICAL SCREENING AND ACUTE ORAL TOXICITY STUDY OF THE FLOWER OF PHLOGACANTHUS THYRSIFLORUS NEES IN ALBINO MICE
Medicinal plants contains a variety of chemical substances with important therapeutic properties that can be utilised in the treatment of human diseases. Phlogacanthus thyrsiflorus Nees of family Acanthaceae is used in f...
ENHANCED BIOAVAILABILITY OF DRUGS VIA INTRANASAL DRUG DELIVEY SYSTEM
The aim of present investigation is to explain the enhancement of bioavailability of drug through intranasal drug delivery system. Intranasal Therapy has been an accepted form of treatment in the Ayurvedic system of Indi...
ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF CURCUMIN BY SOLID DISPERSION TECHNIQUE
Curcumin, a naturally occurring highly lipophilic molecule has wide range of pharmacological activities. However, its limitedaqueous solubility and degradation at alkaline pH restricts its bioavailability. Solid dispersi...
BAUHINIA TOMENTOSA: A PHYTOPHARMACOLOGICAL REVIEW
Bauhinia tomentosa commonly known as Yellow bell orchid tree belongs to Fabaceae family, one of the best, versatile and most commonly used household remedy for many manifestations. It is an erect shrub with downy branche...