A REVIEW ON DRUG SOLUBILITY: IMPORTANCE AND ENHANCEMENT TECHNIQUES
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 7
Abstract
Traditionally, nearly 40% of the new chemical entities (NCEs) identified by pharmaceutical industry screening programs have failed to be developed due to poor water solubility, which makes their formulation difficult or even impossible to come into the regular market. Solubility is one of the important way to achieve the desired concentration of drug into the systemic circulation for its pharmacological response and also most of the drug are weekly acidic and weakly basic with poorly aqueous solubility. The oral route of administration is the most preferred and widely accepted route of delivery due to ease of ingestion for many drugs, However these drugs with slow dissolution rate and low solubility in an aqueous media shows the incomplete absorption leading to low bioavailability when Orally administered poorly soluble drugs often require high doses in order to reach therapeutic plasma concentration of oral concentration because of which increase in the side effects for certain drugs. Pharmaceutical drugs falling under the Biopharmaceutical Classification System (BCS) class ӀӀ and IV are the main emphasis of this review as these drugs are of low solubility. Here we discussed about traditional techniques, novel drug delivery technologies, solid dispersion techniques and to enhance the solubility as well as the bioavailability of low soluble drugs.
Authors and Affiliations
Umesh Pere
Keywords
Related Articles
- EP ID EP627542
- DOI -
- Views 162
- Downloads 0
COMPARATIVE HPLC STUDY OF RELEASE KINETICS OF THE COCRYSTALLIZED AS WELL AS MIXTURE OF ACTIVE PHARMACEUTICAL INGREDIENTS OF ASPIRIN, IBUPROFEN, INDOMETHACIN, DICLOFENAC SODIUM AND PARACETAMOL IN BODY FLUIDS
Aspirin, Ibuprofen, Indomethacin, Diclofenac sodium and Paracetamol are taken as NSAIDs. All drugs have free carboxylic acid group (–COOH) and paracetamol has free phenolic group (–OH) so all are acidic in nature. The co...
FOLATE-CONTAINING NATURAL RESOURCES REVIEW PROSPECTS OF PHARMACOLOGICAL RESEARCH.
Folate is a general term for water-soluble vitamin B, it includes folic acid and its derivatives (diglutamates, triglutamates, polyglutamates), naturally found in foods such as leafy vegetables, leguminous plants, egg yo...
A STUDY ON THE ANTIDIABETIC PROPERTY OF A MIXED HERBAL FOOD
Diabetes mellitus (DM) is a serious metabolic disorder and plenty of medicinal plants are used in traditional medicines to treat diabetes. Abnormality in levels of blood glucose, lipid profile, SGPT, SGOT, and CRP levels...
PERSONALIZED MEDICINE IN NEUROLOGICAL PRACTICE; FOCUS ON MIGRAINES: "A REVIEW"
Background: Scientific advancements offer the potential to define an individual's risk based on their genetic make-up as well as the contribution of genes, proteins, and metabolic pathways to human physiology and variati...
TOWARDS CONVIVIALITY OF SEAMLESSLY INTEGRATED CHANNEL AND AUTOMATION: DESIGN FOR FUTURE GROCERY SHOPPING
Nowadays, leveraging technologies have been put with much more emphasis by industrialized food retailers for overseeing shoppers, reducing loss and popularizing cashier-free. That means millions of American workers behin...