A Review on Recent Advances in Drug Development and Pharmacotherapeutic Approaches for Obesity
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 6
Abstract
Overweight and obesity are defined as abnormal or excessive fat accumulation that presents a risk to health. A crude population measure of obesity is the body mass index (BMI) . A person with a BMI of 30 or more is generally considered obese. A person with a BMI equal to or more than 25 is considered overweight. Obesity is a well-established risk factor for hypertension, hyperlipidemia, type II diabetes, coronary heart disease, stroke, obstructive sleep apnea, asthma, orthopedic disorders, and certain cancers. Despite this risk, the prevalence of obesity continues to increase worldwide, and there is a growing demand for safe and effective antiobesity drugs. Previous antiobesity drugs or anorexigens, particularly centrally acting agents, have poor safety records. Life-threatening safety issues led to the withdrawal of aminorex in 1968, fenfluramine and dexfenfluramine in 1997, and phenyl propanolamine in 2000. Many of the safety issues, such as valvulopathy with fenfluramine and pulmonary arterial hypertension with aminorex, were initially not predicted by routine preclinical toxicology studies. . Meridian(Sibutramine ) was approved by FDA in 1987,Xenical (orlistat) was approved by FDA in 1999, Recently Qsymia (phentermine & topiramate), Belviq(lorcaserin) was approved by FDA in 2012. This review covers the current state of antiobesity drugs and their safety concerns, and highlights new therapeutic targets and also highlights the threats associated with the surgical treatment of obesity as how liposuction surgery recently claim life of JNTU assistant professor.
Authors and Affiliations
Ayesha Siddiqua
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