A REVIEW ON SOLID DISPERSIONS DRUG DELIVERY SYSTEMS
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2012, Vol 2, Issue 4
Abstract
Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. This article reviews the various preparation techniques for solid dispersion. The different types of solid dispersions based on the molecular arrangement have been highlighted. An ideal drug delivery system should be able to deliver an adequate amount of drug, preferably for an extended period of time for its optimum therapeutic activity. Most drugs are inherently not long lasting in the body and require multiple daily dosing to achieve the desired blood concentration to produce therapeutic activity. To overcome such problem, controlled release and sustained release delivery systems are receiving considerable attention from pharmaceutical industries worldwide. A controlled release drug delivery system not only prolongs the duration of action, but also results in predictable and reproducible drug-release kinetics. One advantage of controlled release dosage forms is enhanced patient compliance. Drug delivery systems based on the principles of solid dispersion (1). The enhancement of oral bioavailability of poorly water soluble drugs remains one of the most challenging aspects of drug development.
Authors and Affiliations
Palash Das, Harika Das, Srujan Kumar, Arpita Ghosh, Shehnaz Begum
Keywords
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