A REVIEW ON TECHNIQUES TO IMPROVE SOLUBILITY OF POORLY SOLUBLE DRUGS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 7
Abstract
Solubility is the phenomenon in which the conversion of solute into solution, and it is very important for the absorption, bioavailability and pharmacological response. About 40% new drug has water solubility, which is difficult to formulate. This review gives details about techniques to improve solubility of poorly water soluble drugs, includes particle size reduction, nanosuspension, self emulsifying drug delivery system, liquisolid compact, solid dispersion etc. The selection of solubility enhancement techniques depends on drug property, site of absorption and required dosage form characteristics.
Authors and Affiliations
Harshada Wagh
Keywords
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