A REVIEW ON THE ANALYTICAL TECHNIQUES USED FOR THE DETERMINATION OF PARACETAMOL IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS
Journal Title: Baqai Journal of Health Sciences - Year 2016, Vol 19, Issue 2
Abstract
Paracetamol (PM) is an active metabolite of phenacetin and belongs to p-aminophenol derivatives. It is also termed as acetaminophen. PM is one of the non-steroidal anti-inflammatory drugs (NSAIDs) which is used as an analgesic and antipyretic agent. It is an OTC drug and is used as a common household analgesic. It is not used as a substitute of aspirin or any other NSAIDs. It is a weak cyclooxygenase (COX) 1 and 2 inhibitor but may inhibit COX-3 in the central nervous system. Many analytical techniques have been used for the assay of PM in pharmaceutical preparations and biological fluids. These techniques include spectrometry, chromatography, spectrofluorimetry, chemiluminescence, electrochemical techniques, flow injection spectrometry and chronoamperometry. In many pharmaceutical preparations PM is also used in combination with other drugs and these techniques have also been used for their simultaneous determination. A detailed review of various analytical techniques used for the assay of PM has been carried out which would be of great help to the chemists and pharmacists involved in the analysis and quality control of drugs.
Authors and Affiliations
Aisha Noreen, Kiran Qadeer, Zubair Anwar, Iqbal Ahmad
Keywords
Related Articles
- EP ID EP200229
- DOI -
- Views 120
- Downloads 0
REMEMBERING PROF. DR. FAREEDUDDIN BAQAI
Abstract is not available.
MOLECULAR CHARACTERIZATION OF HEPATITIS C VIRUS AND INTRODUCTION OF BIORISK MANAGEMENT (CWA 15793-2008) AT MIRPUR DISTRICT, AZAD JAMMU AND KASHMIR
The object of the study was to determine the ratio of incidence and genotyping of hepatitis C virus (HCV) infection with reference to different typable and untypable strains in various populations of Mirpur, Azad Jammu a...
ANALYSIS OF AMINO ACIDS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Abstract: Amino acids are the building blocks of proteins and are considered as the key precursors for the formation of hormones and low molecular weight nitrogenous substances with biological importance. Since the analy...
FREQUENCY OF DEPRESSION AND ANXIETY AMONG ADULT EPILEPTIC PATIENTS
Epilepsy is a common neurological disease that greatly affects quality of life. Although not cured but easily managed by anti-epileptic medications, it is known to be associated with many other psychiatric co-morbid cond...
PREVALENCE OF MULTI-DRUG RESISTANT BACTERIAL GASTROENTERITIS IN KARACHI, PAKISTAN
Multidrug resistant Escherichia coli (E. coli) associated diarrheal diseases are the most prevalent health problems in Karachi, Pakistan. The main objective of the present study was to evaluate the clinical experiences o...