A Review onParis Polyphylla Smith: As an Effective andAlternative Treatment of Cancer
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2018, Vol 7, Issue 2
Abstract
Cancer is one of the leading causes of mortality in the world. There are many synthetic drugs available for cancer treatment, but not without side effects. Medicinal plants such as ParisPolyphylla Smith presents an alternative therapeutic drug which iscomparatively less toxic. This review aims to critically analyze the various types of cancer that use the bioactive compounds of the herb for potential treatment. It investigates the types of mechanism, that thesebioactive compoundsinhibit cancer cell lines or nude mice.The article could offer a significant scope for future researchers to dedicate more studiesformany known and unknown compounds of the herb. These unknown compounds could be effective to treat other types of cancer that have not been assessed. The data from the review provide evidence that steroidal saponins such as polyphyllin VI, polyphyllin VII, polyphyllin D, Rhizoma paridis saponins (RPS) as the main bioactive compounds that exhibits cytotoxicity and arrest cell cycle either in S or G2/M phase or both. They trigger apoptosis mainly via mitochondrial-mediated pathway (intrinsic pathway) and death receptor-mediated pathway (extrinsic pathway).
Authors and Affiliations
Arcadius Puwein, Shiny C. Thomas, Laishram Indira Singha
Keywords
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