A Review onParis Polyphylla Smith: As an Effective andAlternative Treatment of Cancer
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2018, Vol 7, Issue 2
Abstract
Cancer is one of the leading causes of mortality in the world. There are many synthetic drugs available for cancer treatment, but not without side effects. Medicinal plants such as ParisPolyphylla Smith presents an alternative therapeutic drug which iscomparatively less toxic. This review aims to critically analyze the various types of cancer that use the bioactive compounds of the herb for potential treatment. It investigates the types of mechanism, that thesebioactive compoundsinhibit cancer cell lines or nude mice.The article could offer a significant scope for future researchers to dedicate more studiesformany known and unknown compounds of the herb. These unknown compounds could be effective to treat other types of cancer that have not been assessed. The data from the review provide evidence that steroidal saponins such as polyphyllin VI, polyphyllin VII, polyphyllin D, Rhizoma paridis saponins (RPS) as the main bioactive compounds that exhibits cytotoxicity and arrest cell cycle either in S or G2/M phase or both. They trigger apoptosis mainly via mitochondrial-mediated pathway (intrinsic pathway) and death receptor-mediated pathway (extrinsic pathway).
Authors and Affiliations
Arcadius Puwein, Shiny C. Thomas, Laishram Indira Singha
Keywords
Related Articles
- EP ID EP401398
- DOI -
- Views 170
- Downloads 0
Shigellosis and Socio-Demography of hospitalized Patients in Kano, North-West, Nigeria.
Aim: The aim of the study was to determine the prevalent of Shigellosis in relation to socio-demographic characteristics of hospitalized patients in Kano metropolis. Study design: The study is a descriptive cross-section...
Antibacterial and Insecticidal Activity of Crude Seed Extracts of Annona squamosa L.
The present investigation was conducted to evaluate the antibacterial and Insecticidal efficiency of traditional plant Annonas quamosa. Seeds extract of plant Annonas quamosa were prepared by methanol extraction method a...
Mechanism of Action and Phytochemicals of Some Potential Analgesic Agents from Indian Natural Product: A Review
Analgesics are class of drugs used to treat pain. Pain is sensory and emotional experience which is unpleasant that doesn’t related with the actual or potential tissue damage or circumstances which depicts the damage its...
Cornea plana: a case report
We report a case of a 7-yeas old boy with Cornea plana who presented with heavy amblyiopia due to high refractive error. Cornea plana is a genetically determined condition that can be accompanied by a range of complicati...
Formulation And Evaluation Of Furosemide Oral Disintegrating Tablets
Orally disintegrating tablets (ODTs) are a rapidly growing category of dosage form in the pharmaceutical industry which has received ever-increasing demand during the last decade. They especially find application in targ...