A Severe Autoimmune-like Anti-Tuberculosis Drug-induced Liver Injury: Case Report and Review
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2018, Vol 8, Issue 3
Abstract
A Severe Autoimmune-like Anti-Tuberculosis Drug-induced Liver Injury: Case Report and Review Jorge R. Mosqueira1, Sue Anicama2, Jorge De Los Ríos3 1Médico Cirujano, Universidad Peruana Cayetano Heredia, Departamento de Medicina Interna, Hospital María Auxiliadora, Lima, Perú 2Médico Cirujano, Universidad de San Martín de Porres, Lima, Perú 3Jefe del Servicio de Neumología “CENEX Niño Jesús”, Hospital María Auxiliadora, Lima, Perú ABSTRACT Drug-induced liver injury is one of the most significant adverse drugs reactions and, in severe cases, could be a potentially life-threatening condition. It can be classified in intrinsic and idiosyncratic reactions and, anti-tuberculous drugs are known to induce the later one. In some cases, it might develop some autoimmune features which represent a challenge for both diagnosis and treatment. We report a 37-year-old woman who was admitted to our hospital with signs of severe acute liver injury. She was diagnosed with autoimmune-like drug-induced liver injury by anti-tuberculous drugs and was treated with corticosteroids, N-Acetylcysteine and Ursodesoxycholic acid. Indeed, based on this case a review of the literature is presented. J Microbiol Infect Dis 2018; 8(3):128-134
Authors and Affiliations
Jorge Mosqueira, Sue Anicama
Keywords
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