A short preliminary experimental study on teratogenic effect of methenamine in embryonic model

Abstract

Methenamine salts have been traditionally used in the veterinary and human medicine, but its use is sometimes associated with some side effects. Toxicopathological effects of methenamine salt have always been a major concern. There is scantly information available about the lesions of methenamine compound in embryo. The objective of this study was to determine the teratogenic effects of methenamine in the chicken embryo. Fertile chicken eggs were divided into four equal treatment groups, 10 eggs per each, as fallow: group 1: no injected group. Group 2: needle-injected group; the needle was insert into yolk sac without any injection. Group 3: phosphate buffered saline-injected group; whose individuals were injected with phosphate buffered saline solution. Group 4, whose individuals were likewise injected with methenamine at dosage of 30 mg/egg at day 4 of incubation. The teratogenic effect of methenamine was revealed as cyst formation instead of abdominal and thoracic body structures. Not recognizable organ was existed in abdominal/thoracic cyst. The normal brain tissue was replaced by large cavity with rim of nervous tissue. The feather formation was also defected. Based on these findings, it is concluded that methenamine at above-mentioned concentration are teratogenic for the chicken embryo. Current study also advises caution in the extended use of methenamine compounds. Further studies are needed to clarify the teratogenic effects of this drug on the development of human fetus.

Authors and Affiliations

Hadi Tavakkoli| Department of Avian Medicine, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran, Amin Derakhshanfar| Department of Pathobiology, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran, Samaneh Noori Gooshki| School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran

Keywords

Related Articles

Changes of seed yield, seed protein and seed oil in rapeseed (Brassica napus L.) under application of different bio fertilizers

This experiment was lay out in order to evaluate the effects of different biofertilizers on seed yield, protein and oil of rapeseed in Iran. The experiment was a factorial design with three replications. Treatments wer...

Survey frequency of verotoxigenic Escherichia coli (VTEC) in raw milk at Kerman city

Diarrhea is an important hygienic problem in under development countries. Among pathogenic agents Escherichia coli is the most etiologic agent of diarrhea in children below five years old. Some E. coli strains produce...

Soil changes induced by hardwood and coniferous tree plantations establishment: Comparison with natural forest soil at Berenjestanak lowland forest in north of Iran

Increasing urbanisation and industrialisation have led to a dramatic reduction in forest area, and now only culturally protected remnants of natural forests and some new plantations remain in most areas of the north of...

Effect of Selenium spraying on yield and growth indices of Wheat (Triticum aestivum L.) under drought stress condition

An experiment was conducted in order to evaluate the effects of Se spraying on yield and growth indices of wheat under drought stress condition, in agriculture and natural resource research center of Tehran province in...

Improvement of Morpho-Physiological Traits and Antioxidant Capacity of Zinnia (Zinnia Elegance ëDreamland Redí) by Arbuscular Mycorrhizal Fungi (Glomus mosseae) Inoculation

Objective: The inoculation of substrates with arbuscular mycorrhizal fungi (AMF) is one of the most important effective strategies applied and one of the aims of sustainable agriculture. Methods: This experiment was co...

Download PDF file
  • EP ID EP12770
  • DOI -
  • Views 625
  • Downloads 31

How To Cite

Hadi Tavakkoli, Amin Derakhshanfar, Samaneh Noori Gooshki (2013). A short preliminary experimental study on teratogenic effect of methenamine in embryonic model. International journal of Advanced Biological and Biomedical Research, 1(12), 1523-1528. https://europub.co.uk/articles/-A-12770