A SIMPLE AND A CHEAP UV ASSAY METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF EPLERENONE IN TABLETS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: To develop a simple and a cheap UV spectrophotometric assay method for the estimation of Eplerenone in tablets and validate as per ICH guidelines.Methods: The optimized method uses 100% potassium dihydrogen orthophosphate, pH 2.0 as a solvent for the estimation of assay of Eplerenone in tablets at a detection wavelength of 245 nm.Results: The developed method resulted in Eplerenone exhibiting linearity in the range 5-15μg/ml. System precision and intra-day precision are exemplified by relative standard deviation of 1.17% and 0.94% respectively. Method was found to be rugged as precision was found to be 1.52%. Percentage Mean recovery was found to be in the range of 98â€102 by percentage method during accuracy studies. Conclusion: A simple and a cheap UV spectrophotometric assay method were developed and validated for the estimation of Eplerenone in tablets as per ICH guidelines and hence it can be used for routine analysis in various pharmaceutical industries.Â
Authors and Affiliations
P. Manasa, Sk Jaffer, M. Ashwini, A. Ashok Kumar
Keywords
Related Articles
- EP ID EP578324
- DOI -
- Views 68
- Downloads 0
MICROBICIDAL POTENTIALITY OF PURIFIED ANTHOCYANIN FROM IN VITRO CULTURE OF CLERODENDRON INFORTUNATUM L. AGAINST SELECTED PATHOGENS
Objective: Clerodendron infortunatum L. is a widely used medicinal herb over centuries for curing many skin-borne disorders. The present study was designed to validate the tribal knowledge by evaluating antimicrobial pot...
SOLUBILITY ENHANCEMENT OF RITONAVIR BY HOT MELT EXTRUSION
Objective: The enhancement of oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Therefore formulation approaches are being explored to enhance bioavailabi...
COST ANALYSIS OF COMMONLY USED DRUGS UNDER PRICE CONTROL IN INDIA: ASSESSING THE EFFECT OF DRUG PRICE CONTROL ORDER ON BRAND PRICE VARIATION
Objective:Â Rising cost of medical therapy is a major concern for patients, and there is high variability in the prices of numerous branded medicines available in India. Drug Price Control Order (DPCO) 2013 was implement...
3D-QSAR, DOCKING STUDY, PHARMACOPHORE MODELING AND ADMET PREDICTION OF 2-AMINO-PYRAZOLOPYRIDINE DERIVATIVES AS POLO-LIKE KINASE 1 INHIBITORS
Objective: The polo-like kinase 1 (plk1) plays important roles in the regulation of mitotic progression, including mitotic entry, spindle formation, chromosome segregation and cytokinesis. Thus, plk1 is considered as a g...
EVALUATION OF IN-VITRO ANTIHELMINTIC PROPERTIES OF THE EXTRACT OF RUSSELIA EQUISETIFORMIS (SCHLECHT. AND CHAM.) SCROPHULARIACEAE
Objective: The present study was aimed to evaluate the in vitro anthelmintic activity of Russelia equisetiformis leaves in comparison with anthelmintic drug Piperazine citrate.Methods: In vitro Anthelmintic activity of d...