A SIMPLE AND ECONOMICAL PROCEDURE FOR SYNTHESIS OF AMANTADINE HYDROCHLORIDE
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 9
Abstract
Amantadine hydrochloride (1), a well-known antiviral drug, has been used to treat certain type-A influenza infections and been also medicated as an anti-dyskinetic agent for Parkinson’s disease. In this paper, we report a simple and economical procedure for synthesis of amantadine hydrochloride (1) from 1-bromoadamantane (3) and urea in a one-step procedure with high yield (81%) and advantage. The structure of the obtained amantadine hydrochloride was confirmed by MS, 1H-NMR and 13C-NMR spectra and its quality was validated following the United State Pharmacopeia (USP 38). In addition, the synthesis condition was optimized following parameters including reaction reagent as source of nitrogen, reaction temperature, reaction time, reagent molar-ratio, solvent and HCl concentration, successively, to archive the highest yield of amantadine hydrochloride (1) at the following certified condition: reaction temperature = 175°C; reaction time = 1.0 h; molar ratio of (urea: 1-bromo-adamantane) = (3 : 1), in diphenyl ether with ratio of (Ad-Br : Ph2O) = 1.1 g :1 mL), respectively.
Authors and Affiliations
D. C. Phan et al.
Keywords
Related Articles
- EP ID EP627617
- DOI 10.13040/IJPSR.0975-8232.10(9).4359-66
- Views 163
- Downloads 0
ALLELOPATHIC POTENTIAL OF LEAF LEACHATES OF CHROMOLAENA AND LANTANA ON MUNG BEAN (VIGNA RADIATA L. CV. K-851) SEEDS
Chromolaena and Lantana plants were analyzed to evaluate the existence of allelopathic effect using fully viable seeds of mung bean as the bioassay material. The study shows that pretreatment of mung bean seeds with vari...
FORMULATION AND EVALUATION OF ENTERIC COATED ASPIRIN TABLET BY USING BIOEPOXY RESIN AS COATING MATERIAL
An enteric coating is a polymer barrier applied to oral tablets; it prevents dissolution and disintegration of tablet in the gastric environment. Some drugs like aspirin that have an irritant effect on the GI Track after...
GC- MS ANALYSIS AND IN-SILICO DOCKING ANALYSIS OF METHANOLIC EXTRACT OF FICUS RACEMOSA BARK
Indian medicinal plants are considered as a vast source of several pharmacologically active principles and compounds, which are commonly used in home remedies against multiple ailments. Plant secondary metabolites such a...
CITRULLUS COLOCYNTHIS PHYTOSOMES: DEVELOPMENT AND PHYSIOCHEMICAL CHARACTERIZATION
Present work is aimed at development and characterization of phytosomes, novel drug delivery dosage form used to improve the bioavailability of the drug, containing ethanolic, aqueous, dichloromethane and ethyl acetate e...
ANTI-DIABETIC ACTIVITY OF HYDROALCOHOLIC EXTRACTS OF ANACARDIUM OCCIDENTALE, AEGLE MARMELOS AND ACHYRANTHES ASPERA IN ALLOXAN-INDUCED DIABETIC RATS
Diabetes mellitus is a major endocrine metabolic disorder of multiple etiologies characterized by chronic hyperglycemia; with disturbances of carbohydrate, protein, and fat metabolism. It is caused by the deficiency or i...