A SIMPLE EFFORT TO ENHANCE SOLUBILITY AND DISSOLUTION RATE OF SIMVASTATIN USING CO-CRYSTALLIZATION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 8
Abstract
Objective: The main objective of this study was to explore co-crystallization as an effort to enhance the solubility of simvastatin (SV) using tartaric acid (TA) as co-former.Methods: The simulation of molecular modeling of TA against SV has been done by in silico using auto dock 4.2. A preparation of co-crystal carried out by using solvent drops grinding (SGD) with an equimolar ratio. A co-crystal formed was confirmed by scanning electron microscopy (SEM), saturated solubility test, in vitro dissolution test, infrared spectrophotometry (FTIR), powder X-ray diffraction (PXRD), and differential scanning calorimetry (DSC).Results: The in silico studies showed that the interaction of TA and SV has synthon molecular by hydrogen bonding. An increasing of solubility and in vitro dissolution profile of co-crystal resulted as compared to the value of pure SV and its physical mixer. Characterizations of a co-crystal SV: TA (1: 1) including SEM, FTIR, PXRD, and DSC have indicated the formation of new solid crystal phase that different compared to SV, TA, and its physical mixture.Conclusion: The co-crystallization has been used to enhance the solubility and dissolution of simvastatin. All characterization either in silico and in vitro has shown the formation of co-crystal SV: TA (1:1).
Authors and Affiliations
Iyan Sopyan, Achmad Fudholi, Muchtaridi Muchtaridi, Ika Puspitasari
Keywords
Related Articles
- EP ID EP576156
- DOI -
- Views 70
- Downloads 0
ANTI-ULCER STUDY OF STANDARDIZED ETHANOL ROOT EXTRACT OF AGANOSMA DICHOTOMA AND ISOLATED URSOLIC ACID
Objective: Aganosma dichotoma K. Schum (Apocynaceae) has been traditionally used as an Ayurvedic ulcer treatment and the study scientifically validates the antiulcer effect of A. dichotoma ethanol root extract (EAD).Meth...
DISSOLUTION BEHAVIOR OF CARBAMAZEPINE SUSPENSIONS USING THE USP DISSOLUTION APPARATUS 2 AND THE FLOW-THROUGH CELL METHOD WITH SIMULATED GI FLUIDS
Objective: To characterize the dissolution behaviour of carbamazepine generic suspensions using the USP Dissolution Apparatus 2 and the flow-through cell method with simulated gastrointestinal fluids as dissolution media...
EXPERIMENTAL EVIDENCES FOR THE PROMISING HERAPEUTIC ROLE OF VITIS VINIFERA SEED EXTRACT AGAINST NONALCOHOLIC STEATOHEPATITIS
Objective: The present study was planned to investigate the possible therapeutic effect of methanolic extract of Vitis vinifera seeds on high fat diet-induced nonalcoholic steatohepatitis (NASH) in forty adult female Wis...
ASSESSMENT OF SECONDARY METABOLITES WITH RELATION TO THEIR ANTIOXIDANT ACTIVITY OF FUNGAL ENDOPHYTES ISOLATED FROM MEDICINAL PLANTS
Objective: The detection of fungal endophytes and assessment of their antioxidant activity isolated from two medicinally important plants, Calotropis procera (L.) R. Br. and Catharanthus roseus (L.) G. Don. from parts of...
STABILITY STUDIES ON FLUCLOXACILLIN SODIUM IN RECONSTITUTED ORAL SUSPENSIONS
Objective: Stability studies on flucloxacillin sodium in reconstituted oral suspensions were carried out. The experiment sought to investigate the effects that the different types of water for reconstitution and differen...