A single administration of fish oil inhibits the acute inflammatory response in rats
Journal Title: Asian Pacific Journal of Tropical Medicine - Year 2017, Vol 10, Issue 8
Abstract
Objective: To investigate the antiinflammatory effects of a single administration of fish oil (FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil (FOP) orally administered in a single dose in rats. Nitric oxide (NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment (30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP (300 mg/kg) reduced NO, TNF-a, IL-1b, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein.
Authors and Affiliations
Ciomar Aparecida Bersani-Amado
Keywords
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- EP ID EP279741
- DOI 10.1016/j.apjtm.2017.07.019
- Views 51
- Downloads 0
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