A single center series highlights on incidence and management of gastric neuroendocrine tumours with literature review
Journal Title: Journal of Cancer Research & Therapy - Year 2015, Vol 3, Issue 5
Abstract
Neuroendocrine tumours of the digestive system (GEP-NET) are relatively rare. Nevertheless, their diagnoses is rising as seen from studies in the US and elsewhere. Gastric neuroendocrine tumours (Gastric NETs) vary through a wide clinical spectrum, from asymptomatic cases to functioning tumours. Gastrointestinal specialists need to be aware and pursue these lesions as they are indolent with a malignant variant and a potential for metastasis. A computerised search through our pathology laboratory data base, using codes for gastric, carcinoid and neuroendocrine tumour/ hyperplasia, was used to identify cases from January 2008 to September 2014. Medical charts were retrieved, examined. Eleven cases were identified and re-examined by one consultant pathologist. There were 5 females - mean age of 50 years (39-59) and 6 males - mean age of 57 years (41-73). Mean follow up period was 4.5 years (1-9). Gastric NETs fall into Type I, II and III (WHO Classification). Our series showed eight cases of Type I managed by biopsy/ endoscopic mucosal resection (EMR). No Type II cases were identified and one case of Type III had a subtotal gastrectomy and lymphadenectomy. Two neuroendocrine hyperplasia cases were managed by biopsy only. Cases were followed up (except one who refused) with regular upper endoscopy and imaging as indicated. A literature review of managing Gastric NETs was discussed. We aim to alert gastrointestinal specialists by presenting a retrospective study of Gastric NETs from a single teaching institution.
Authors and Affiliations
Fahmy WF, Khokhar HA, Meshkat B, Babikir S, Azeem B, Tobbia IN
Keywords
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- EP ID EP545586
- DOI 10.14312/2052-4994.2015-9
- Views 54
- Downloads 0
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