A strategy to enhance bioavailability of drug candidates: Natural Bioenhancers
Journal Title: International Journal of Pharmaceutical and Bio-Medical Science - Year 2021, Vol 1, Issue 01
Abstract
International Journal of Pharmaceutical and Bio-Medical ScienceISSN(print): Applied, ISSN(online): AppliedVolume 01Issue 01 February 2021Page No : 10-1410Volume 01 Issue 01 February 2021 Corresponding Author: Dr. SamaVenkateshA Strategy toEnhance Bioavailability of Drug Candidates: NaturalBioenhancersNishat Ara1, Thaiseen Sultana2, Rajesh Bolleddu3, Dr.Sama Venkatesh4, A Ravi Kiran51,2,4,5G. PullaReddyCollege of Pharmacy, Mehdipatnam, Hyderabad-500 028, Telangana, India3Central Ayurveda Research Institute, CCRAS,Ministry of AYUSH,Kolkata, West Bengal-700 091, IndiaABSTRACTARTICLE DETAILSNowadays herbs are increasingly being used worldwideas therapeutic agents or in collaborationwith minerals and vitamins in health supplements, teas etc.There are many advantages of herbalism over modern or conventional medicine such as the herbal/traditional systems of medicine causeslesser side effects than modern medicine; herbal medicine along with lifestyle modification enhances its potency by assisting and boosting the inborn self-healing mechanismsof the patient. Thus, the chronic disorder is not only cured but the possibilities of its recurrence arehighly reduced.However, despite having great in-vitro potential, herbsor herbal extracts have demonstrated very less in-vivo activity due to insufficientlipid solubility andirregular molecular size. Thus,this led to poor absorption andpoor bioavailability. With the advancement in science and technology, several trials areundergoneto enhancethe bioavailability of drugs via novel drug delivery systems such as microspheres, nanoparticles, liposomes, transferosomes, lipid-based systems, etc. Besides these novel approaches, there are certain compounds that exist in nature that are found to exhibit enhanced bioavailability rate such as piperine, curcumin, naringin, quercetin, genistein, etc. The objective of this review is to throw light on bioavailability enhancing effects of these natural bioenhancers of herbal origin, their characteristic features and mechanisms of action
Authors and Affiliations
Nishat Ara, Thaiseen Sultana, Rajesh Bolleddu, Dr. Sama Venkatesh, A Ravi Kiran
Keywords
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