A study establishing correlation of proteinuria and urine protein/creatinine ratio with disease severity in pediatric dengue fever
Journal Title: IP International Journal of Medical Paediatrics and Oncology - Year 2017, Vol 3, Issue 1
Abstract
Dengue fever has emerged as a major health problem globally with several complications occurring which lead to increasing morbidity and mortality particularly in children. It has therefore become important to establish accurate, easy to perform predictors of disease severity to enable timely management and prevent associated complications. Such markers have not been well researched in the paediatric population. The study was undertaken to establish early predictors of disease severity viz urine protein creatinine ratio (UPCR) and proteinuria in children with dengue. All of the 76 children hospitalized with dengue fever were categorized according to disease severity as per WHO guidelines. Of these, 25% had category 1 disease, 36.8% had category 2 and 38.2% category 3 disease. All children were classified according to UPCR into 4groups. It was observed that 34.2% had UPRC <0.5, 26.3% had 0.5-1.0, 26.3% had 1-3 and 13.2% children had UPRC >3. UPRC was inversely proportional to age and had no association with gender. There was a positive correlation between UPRC and the severity of illness in dengue fever. The association of occurrence of bleeding manifestations, requirement of inotropes and outcome with UPCR was statistically significant. Significant proteinuria had a statistically significant association with mortality, but did not correlate well with disease severity. Thus both UPCR and proteinuria assessment appear to be useful tools for deciding hospitalization, management as well as prognostication in childhood dengue fever.
Authors and Affiliations
Priyanka Datla, Uma Raju, Padmanabh Reddy, Srikrishna Sv, Tejas Deshmukh
Keywords
Related Articles
- EP ID EP300693
- DOI 10.18231/2455-6793.2017.0008
- Views 135
- Downloads 0
Survival of dengue children in a tertiary care centre
Background: Dengue infection is an emerging disease and is a major health problem in our country. The annual incidence is estimated to be 7.5 to 32.5 million and case fatality is around 5%. There are few articles on deng...
Maternal risk factors and outcome of low birth weight babies admitted to a Gujarat Adani Institute of Medical Science, Bhuj, Kutch, Gujarat, India- A cross-sectional study
Aim: Present study was conducted to know the maternal risk factors and outcome of low birth weight babies in Department of Pediatrics, Gujarat Adani Institute of Medical Science, Bhuj, Kutch, Gujarat, India. Materials an...
Comparison of total antioxidant capacity in term small for gestational age (SGA) and appropriate for gestational age (AGA) newborns
Background: Total antioxidant capacity (TAC) is a measure of oxidative stress. Oxidative stress has been implicated in the pathogenesis of many diseases of newborns. The objective of this study was to estimate total anti...
Developmental Outcome of Nicu Graduate Weighing Less than 2500 Grams in A Tertiary Care Hospital
Background and objective: The early intervention programmes designed for low birth weight babies can be beneficial to improve the prognosis in terms of physical growth and neurodevelopmental outcome. The purpose of this...
A Rare Association of Autosomal Recessive Polycystic Kidney (ARPKD) Disease with AV Canal Defect
ARPKD is an autosomal recessive condition characterized by cystic dilations of the renal collecting tubules. The incidence of ARPKD is estimated to be between 1 in 10,000 - 40,000. It is the most common childhood-onset c...