A STUDY OF ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF CLINICAL ISOLATES OF ACINETOBACTER SPECIES AT A TERTIARY CARE HOSPITAL IN CENTRAL INDIA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 1
Abstract
BACKGROUND Acinetobacter have been implicated in a variety of nosocomial infections including ventilator associated pneumonia, bacteraemia, urinary tract infection, secondary meningitis and in patients confined to hospital intensive care units. Multidrug resistant Acinetobacter species have limited the options for effective treatment. The present study was undertaken to isolate and identify the multidrug resistant (MDR) and pan drug resistant (PDR) Acinetobacter species and also to determine minimum inhibitory concentration of tigecycline using agar dilution method. MATERIALS AND METHODS This is a prospective study conducted over a period of 22 months (January 2014 to October 2015) in a tertiary care hospital. Ninety-six non-duplicate clinical isolates of Acinetobacter species were processed for species identification by standard Microbiological procedures. Antimicrobial susceptibility of these isolates was performed by Kirby-Bauer disc diffusion method and minimum inhibitory concentration of Tigecycline was tested using agar dilution method. RESULTS A. baumannii was the most common species isolated accounting for 82.29% followed by A. calcoaceticus (10.41%), A. haemolyticus (3.12%), A. lwoffii (3.12%) and A. junii (1.04%). Isolates from ICU specimens is significantly higher than ward (p value < 0.05). 89 (92.71%) out of 96 Acinetobacter isolates were multidrug resistant and there was no isolate which was found to be PDR. By MIC agar dilution methods for tigecycline, 82 (85.41%) isolates were found to be sensitive to tigecycline. CONCLUSION Increasing use of antibiotics in hospitals is leading towards antibiotic resistance, which in turn exerts selective pressure on Acinetobacter in hospital environment. Continued surveillance combined with preventive measures remains absolutely essential in efforts to prevent or limit spread of Acinetobacter and resulting infections.
Authors and Affiliations
Minal Vasant Kusalkar, Agrawal Seema M, Katkar Vyankatesh J
Keywords
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- EP ID EP284500
- DOI 10.14260/jemds/2018/14
- Views 99
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