A STUDY OF ASSOCIATION OF ALBUMIN AS PROGNOSTIC VALUE IN DISEASED CONDITION BY CONSIDERING THE HYPERINFLAMMATORY STATES BY HYSTOPATHOLOGICAL SLIDES:
Journal Title: IJSR-International Journal Of Scientific Research - Year 2018, Vol 7, Issue 3
Abstract
Albumin is associated with hyperinflammatory states which renders the delayed wound healing is a known fact1. In cases of a pathological state there might be a low formation of the albumin in liver or high degradation of the albumin. In either of the ways the serum albumin will be lowered. Stress and strain is also known to cause hypoalbuminemia i.e low serum level of albumin. Since albumin is a protein it has to be transcribed rom the genes and studies have shown that TNF - alpha supresses this transcription process. The TNF – alpha is known to increase in any inflammation and thus forms a cascade. In case of hospitalised patients the stress and strain in pre surgical patients and chronically hospitalised patients the serum albumin levels are known to be less than normal. In chronically hospitalised patients the nutritional cause can also be taken into consideration for lower serum albumin levels. Early detection of these low levels of serum albumin levels helps the surgeons and the physicians to intervene and thus cut off the progression of the disease. A sincere effort has been made in this study to understand the relations of the serum albumin level and its effects on the prognosis of the disease and outcome of the surgery if the patient is undergoing any. This study is intended to help the physician, surgeon and general practitioners to understand and intervene in the event and thus help the patient to recover earlier and in a better way. The study has been done in the Department of Pathology, Kanachur Institute of Medical Sciences, Deralakatte, Mangalore. The patients were mainly observed in the Department of Surgery, Emergency Medicine and Casualty. The study was done from January 2017 To December 2017 . In the present study there is a significant difference in the prognosis of the patients when the serum albumin level increases in the serum. The mean serum levels in the three groups were found to be 1.95 gm / Dl, 2.85 gm / Dl and 5.1 gm / Dl. In the third group the complications were not present at all, showing the significance of serum albumin levels in the prognosis and outcome of the disease. The disease prognosis was significantly altered when the low serum albumin was altered.
Authors and Affiliations
Dr Suchithra A Shetty, Dr Indira. S. Puthran
Keywords
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