A STUDY OF BACTERIAL ISOLATES AND THEIR SENSITIVITY PATTERN TO ANTIBIOTICS IN EMPYEMA THORACIS CASES IN A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 38
Abstract
BACKGROUND Empyema thoracis refers to accumulation of pus in the pleural space. The pathogenic organisms isolated in cases of empyema depend on prior antibiotic use and route of infection i.e. whether infection arises as a complication of pneumonia or following oesophageal surgery. It also depends on the age of the patient and presence of co-morbid illness. MATERIALS AND METHODS It is a descriptive study. It was designed to investigate the bacterial isolates of thoracic empyema and to find out the antibiogram pattern of the isolated organisms in a tertiary care hospital over one-year period. In this study, bacteriological spectrum was analysed in 50 empyema cases. Samples of pleural fluid were sent for bacterial culture (Aerobic) and for Gram’s stain as well as for cytologic studies and mycobacterial and fungal smears and cultures, also if clinically indicated Cartridge Based Nucleic Acid Amplification test (CBNAAT). Patients with tubercular empyema were excluded. RESULTS 24 cases were culture positive. Among the 24 culture positive cases, Streptococcus pneumoniae was the commonest bacterium isolated followed by Staphylococcus aureus. A strong inverse correlation was found between prior antibiotic use with chance of culture positivity. In present study Gram-positive organisms were found to be most sensitive to Vancomycin, Linezolid and some are sensitive to Clindamycin, Ciprofloxacin, Levofloxacin and Co-amoxyclav. Gram negative organisms were mostly sensitive to Ceftriaxone, Cefoperazone, Cefepime, Piperacillin-Tazobactam, Meropenem and Colistin. All the strains of Pseudomonas aeruginosa were sensitive to Amikacin. Resistance to Co-amoxyclav was noted in many strains of the Gram negative organisms except Klebsiella. CONCLUSION Gram positive organisms were the commonest organisms isolated in our study. This study also supports the view that prior antibiotic use reduces the chances of detecting the micro-organism through culture and determination of sensitivity.
Authors and Affiliations
Amiya Kumar Dwari, Sumanta Jha, Somnath Sarkar, Swapnendu Misra, Subhankar Chakraborty, Abhijit Mandal
Keywords
Related Articles
- EP ID EP548069
- DOI 10.14260/jemds/2018/934
- Views 68
- Downloads 0
SECONDARY INFECTIONS IN SWINE FLU
[b] BACKGROUND AND OBJECTIVE[/b]: Swine influenza is respiratory disease of pigs caused by type A influenza virus that causes regular outbreak in pigs. Human to human transmission occurs. Some people develop sev...
A QUASI EXPERIMENTAL STUDY OF THE TREATMENT OF ACUTE INTERNAL HAEMORRHOIDS WITH MICRONISED FLAVONOIDS AND SCLEROTHERAPY IN A TEACHING HOSPITAL OF TRIPURA
BACKGROUND Haemorrhoids is a common disease affecting people of all ages and both sexes. Though there is consensus on the treatment of 3rd and 4th degree haemorrhoids, there is still confusion regarding the treatment of...
PATTERN OF CHEST INJURIES IN FATAL ROAD TRAFFIC ACCIDENTS- AN AUTOPSY STUDY
BACKGROUND India is a signatory to the Brasilia declaration and is committed to reduce the number of road accidents and fatalities by 50% by 2020. However, with one of the highest motorisation growths in the world accomp...
COMPARISON OF LIGHT’S CRITERIA AND PLEURAL FLUID CHOLESTEROL TO DISTINGUISH EXUDATIVE AND TRANSUDATIVE PLEURAL FLUID
BACKGROUND Light’s criteria is the gold standard to differentiate transudative pleural effusion from exudative pleural effusion, but it requires four biochemical estimations which in developing countries such as India, m...
MICROBIOLOGICAL PROFILE OF DERMATOPHYTE INFECTIONS IN A TERTIARY CARE HOSPITAL
BACKGROUND Dermatophytosis refers to fungal infection of skin, hair and nails (keratinised tissue). The fungi causing these superficial mycoses belong to three genera Trichophyton, Microsporum and Epidermophyton. These f...