A STUDY OF BACTERIAL ISOLATES AND THEIR SENSITIVITY PATTERN TO ANTIBIOTICS IN EMPYEMA THORACIS CASES IN A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 38
Abstract
BACKGROUND Empyema thoracis refers to accumulation of pus in the pleural space. The pathogenic organisms isolated in cases of empyema depend on prior antibiotic use and route of infection i.e. whether infection arises as a complication of pneumonia or following oesophageal surgery. It also depends on the age of the patient and presence of co-morbid illness. MATERIALS AND METHODS It is a descriptive study. It was designed to investigate the bacterial isolates of thoracic empyema and to find out the antibiogram pattern of the isolated organisms in a tertiary care hospital over one-year period. In this study, bacteriological spectrum was analysed in 50 empyema cases. Samples of pleural fluid were sent for bacterial culture (Aerobic) and for Gram’s stain as well as for cytologic studies and mycobacterial and fungal smears and cultures, also if clinically indicated Cartridge Based Nucleic Acid Amplification test (CBNAAT). Patients with tubercular empyema were excluded. RESULTS 24 cases were culture positive. Among the 24 culture positive cases, Streptococcus pneumoniae was the commonest bacterium isolated followed by Staphylococcus aureus. A strong inverse correlation was found between prior antibiotic use with chance of culture positivity. In present study Gram-positive organisms were found to be most sensitive to Vancomycin, Linezolid and some are sensitive to Clindamycin, Ciprofloxacin, Levofloxacin and Co-amoxyclav. Gram negative organisms were mostly sensitive to Ceftriaxone, Cefoperazone, Cefepime, Piperacillin-Tazobactam, Meropenem and Colistin. All the strains of Pseudomonas aeruginosa were sensitive to Amikacin. Resistance to Co-amoxyclav was noted in many strains of the Gram negative organisms except Klebsiella. CONCLUSION Gram positive organisms were the commonest organisms isolated in our study. This study also supports the view that prior antibiotic use reduces the chances of detecting the micro-organism through culture and determination of sensitivity.
Authors and Affiliations
Amiya Kumar Dwari, Sumanta Jha, Somnath Sarkar, Swapnendu Misra, Subhankar Chakraborty, Abhijit Mandal
Keywords
Related Articles
- EP ID EP548069
- DOI 10.14260/jemds/2018/934
- Views 83
- Downloads 0
TO COMPARE THE ANALGESIC EFFICACY OF 0.25% BUPIVACAINE AND 0.25% ROPIVACAINE IN TAP BLOCK AS A PART OF A MULTIMODAL ANALGESIA REGIMEN FOR POST CAESAREAN DELIVERY PAIN MANAGEMENT
BACKGROUND Women having a caesarean delivery present a unique set of challenges to the Anaesthetist postoperatively. They need to be alert, comfortable and ambulant in order to care for their newborn.[1] As part of a mul...
COMPARISON OF EXTRACORPOREAL LAPAROSCOPIC ASSISTED APPENDECTOMY WITH CONVENTIONAL LAPAROSCOPIC APPENDECTOMY IN UNCOMPLICATED CASES OF APPENDICITIS
BACKGROUND Appendectomy is the most commonly performed intra-abdominal operation. The study was conducted to compare extracorporeal laparoscopic assisted appendectomy with conventional laparoscopic appendectomy in uncomp...
COMPLICATIONS OF PANCREATITIS- CT EVALUATION
BACKGROUND Acute pancreatitis is a common condition with variable clinical course. Imaging studies play an important role in diagnosis and management of acute pancreatitis. Computed Tomography (CT) is undertaken to deter...
THE ROLE OF MOFS IN OUTCOME IN PATIENTS WITH SEPTIC SHOCK
BACKGROUND Multiple organ failure (MOF) is the main cause of death in ICUs, especially affecting septic patients. Infections are the primary outcome determinant of the MOFS in patients with septic shock. This is a prospe...
ASSESSMENT OF CLINICAL AND BIOCHEMICAL PARAMETERS OF ACUTE PANCREATITIS- A CROSS SECTIONAL STUDY
BACKGROUND Acute pancreatitis is a common disease with wide clinical variation and its incidence is increasing. The average mortality rate in severe acute pancreatitis approaches 2–10 %. Severe acute pancreatitis (SAP) d...