A STUDY OF BACTERIAL ISOLATES AND THEIR SENSITIVITY PATTERN TO ANTIBIOTICS IN EMPYEMA THORACIS CASES IN A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 38
Abstract
BACKGROUND Empyema thoracis refers to accumulation of pus in the pleural space. The pathogenic organisms isolated in cases of empyema depend on prior antibiotic use and route of infection i.e. whether infection arises as a complication of pneumonia or following oesophageal surgery. It also depends on the age of the patient and presence of co-morbid illness. MATERIALS AND METHODS It is a descriptive study. It was designed to investigate the bacterial isolates of thoracic empyema and to find out the antibiogram pattern of the isolated organisms in a tertiary care hospital over one-year period. In this study, bacteriological spectrum was analysed in 50 empyema cases. Samples of pleural fluid were sent for bacterial culture (Aerobic) and for Gram’s stain as well as for cytologic studies and mycobacterial and fungal smears and cultures, also if clinically indicated Cartridge Based Nucleic Acid Amplification test (CBNAAT). Patients with tubercular empyema were excluded. RESULTS 24 cases were culture positive. Among the 24 culture positive cases, Streptococcus pneumoniae was the commonest bacterium isolated followed by Staphylococcus aureus. A strong inverse correlation was found between prior antibiotic use with chance of culture positivity. In present study Gram-positive organisms were found to be most sensitive to Vancomycin, Linezolid and some are sensitive to Clindamycin, Ciprofloxacin, Levofloxacin and Co-amoxyclav. Gram negative organisms were mostly sensitive to Ceftriaxone, Cefoperazone, Cefepime, Piperacillin-Tazobactam, Meropenem and Colistin. All the strains of Pseudomonas aeruginosa were sensitive to Amikacin. Resistance to Co-amoxyclav was noted in many strains of the Gram negative organisms except Klebsiella. CONCLUSION Gram positive organisms were the commonest organisms isolated in our study. This study also supports the view that prior antibiotic use reduces the chances of detecting the micro-organism through culture and determination of sensitivity.
Authors and Affiliations
Amiya Kumar Dwari, Sumanta Jha, Somnath Sarkar, Swapnendu Misra, Subhankar Chakraborty, Abhijit Mandal
Keywords
Related Articles
- EP ID EP548069
- DOI 10.14260/jemds/2018/934
- Views 56
- Downloads 0
RUPTURED POSTERIOR COMMUNICATING ARTERY ANEURYSM IN A PRIMIGRAVIDA
PRESENTATION OF CASE A 20-year-old primigravida at 8 weeks of gestation presented to us with history of drooping of the right upper eyelid. It was associated with pain over the upper part of right side of face. She had h...
A STUDY TO KNOW THE PATTERN OF PULMONARY FUNCTION IMPAIRMENTS IN CURED PULMONARY TUBERCULOSIS CASES
BACKGROUND India is the highest TB burden country in the world and patients with treated TB may remain lifelong sufferers of disabling sequelae. In cured pulmonary tuberculosis patients, many survivors develop into pulmo...
ONE YEAR FOLLOW-UP STUDY OF QUALITY OF LIFE AMONG OPIOID SUBSTITUTION THERAPY CLIENTS
BACKGROUND Opioid Substitution Therapy (OST) is a process in which opioid-dependent injecting drug users (IDUs) are provided with longacting opioid agonist medications like buprenorphine for a long period of time under m...
FINE NEEDLE ASPIRATION DIAGNOSIS OF PANCREATIC CARCINOMA {ACINAR CELL CARCINOMA} – CASE REPORT
Acinar cell carcinoma of the pancreas is a rare neoplasm. Pe-operative percutaneous, ultrasound guided (USG), fine needle aspiration cytology (FNAC) of pancreatic lesions is a good modality for obtaining early...
HISTOMORPHOLOGICAL ANALYSIS OF MIXED BAG OF MEDIASTINAL LESIONS IN A TERTIARY CARE CENTRE
BACKGROUND Mediastinum is a Pandora’s box consisting of variety of non-neoplastic and neoplastic lesions, which present as masses. Aims and Objectives- The purpose of this study is to emphasise the role of CT-guided Tru-...