A Study of Cardiac Autonomic Neuropathy and Its Correlation with QTc Dispersion in Type-2 Diabetes Mellitus
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 16, Issue 8
Abstract
Aims: To evaluate the presence of cardiac autonomic neuropathy in Type-2 Diabetes and to correlate autonomic dysfunction with QTc dispersion. Study Design: This was a hospital based cross-sectional study carried out in the department of Medicine JSS Hospital Mysore, India between March 2012 and March 2013. Methodology: We included 50 Diabetes patients (Cases) and 50 Non Diabetes healthy adults (Controls) of both genders. Five standard cardiovascular response tests were carried out (Valsalva ratio, expiration-inspiration ratio, immediate heart rate response to standing, fall of systolic blood pressure on standing and sustained hand grip test) to determine the severity of cardiac autonomic neuropathy. QTc dispersion was determined by subtracting heart rate-corrected minimum QTc interval (QTc min) from maximum QT interval (QTc max) from standard electrocardiogram. Results: 17 patients (34%) had evidence of cardiac autonomic neuropathy. Of this 8 (16%) had borderline and 9(18%) had abnormal CAN. In the control group only 1(2%) had CAN. (P value of 0.000) Mean QTc in cases was 41.60+/-18.11) and in controls was 20.80(+/-4.88) QTc dispersion was 32.7(+/-13.0) in those without CAN and 48.75(+/-9.71) in borderline CAN and 67.77(+/-9.71_in abnormal CAN group. (P =0.000). Conclusion: Prolonged QTc a feature of autonomic dysfunction due to diabetes. QTc dispersion correlates significantly with presence of cardiac autonomic neuropathy and may be a simple and useful measure for detection of cardiac autonomic neuropathy.
Authors and Affiliations
M. Mahesh, M. A. Sandeep, P. K. Kiran
Keywords
Related Articles
- EP ID EP341552
- DOI 10.9734/BJMMR/2016/27201
- Views 61
- Downloads 0
A Pilot Study of Family Stigma in Alzheimer’s Disease: Slovenian Perspective
Since the population of patients with AD is growing and the disease is affecting more and more people, the main goal of this paper was to investigate the process of stigmatisation of family caregivers, when a family memb...
A Female Child with Oligodontia in Primary Dentition – Report of a Rare Case
Aims: Non-Syndromic congenital absence of primary dentition is rare. A female child with congenital absence of primary incisors (n=6) is presented. Presentation of Case: A 4 year-old non-syndromic female child reported w...
A Systematic Review of Elective, Urgent and Emergency Cervical Cerclage and Pregnancy Outcomes
Introduction: Different cervical cerclage namely elective, urgent and emergency are in practice and they aim to improve the maternal and perinatal outcomes. Methods: The aim of this systematic review and analysis is to a...
A Cross-sectional Study of the Prevalence of Asymptomatic Bacteriuria among HIV-positive and HIV-negative Expectant Mothers in a Tertiary Health Centre in South Eastern Nigeria
Background: Asymptomatic Bacteriuria (ASB) in pregnancy is associated with potential urinary and obstetric complications. The diagnosis and management of ASB in expectant mothers is in keeping with safe motherhood initia...
Resistant Nephrotic Syndrome: Review of Trials Using ACTH and a Case Series of Six Patients Treated with ACTHar
Nephrotic syndrome (NS) is associated with edema, proteinuria, hyperlipidemia, and an increased risk for deep vein thrombosis. Therapy may include glucocorticoids, immunosuppressive therapy, and/or chemotherapy. Each is...