A STUDY OF CENTRAL CORNEAL THICKNESS AND CORNEAL ENDOTHELIAL CHANGES IN TYPE 2 DIABETES MELLITUS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 4
Abstract
BACKGROUND Corneal endothelium plays an important role in maintaining the corneal transparency. Evaluation of corneal endothelial cell morphology and central corneal thickness (CCT) is important in a wide range of disorders. Type 2 diabetes mellitus is one of the emerging health problems which also affects the corneal endothelial morphology and CCT. Aims and Objectives- To compare CCT and corneal endothelial changes in type 2 diabetics and non-diabetic controls and to assess their correlation with duration of diabetes and HbA1c levels. MATERIALS AND METHODS A total of 200 eyes of type 2 diabetic subjects and 200 eyes of non-diabetic age and gender matched controls, presenting to the Department of Ophthalmology, Christian Medical College, Ludhiana were included in the study. The study was conducted over a period of one year and eight months. The CCT and corneal endothelial changes were measured using a specular microscope. Data was analysed using SPSS software version 21 using independent t-test, chi-square test and Spearmen correlation test. RESULTS The diabetic subjects had increased central corneal thickness, less endothelial cell density and more standard deviation and hexagonality of the corneal endothelium than the non-diabetic controls (P<0.05). Coefficient of variation for cell size was significantly higher for diabetics (P<0.05). It was observed that the central corneal thickness and corneal endothelial parameters had statistically significant correlation with the duration of diabetes mellitus. Whereas when correlated with HbA1c only CCT and CV had a statistically significant correlation (p=0.041 and p=0.001 respectively). CONCLUSION Diabetics have thicker corneas, less corneal endothelial cell density and hexagonality, and more irregular cell size. Therefore, routine assessment of central corneal thickness and corneal endothelial structure may be beneficial in all diabetic patients along with retinopathy assessment.
Authors and Affiliations
Anubhav Baveja, Nitin Batra, Gurvinder Kaur
Keywords
Related Articles
- EP ID EP610101
- DOI 10.18410/jebmh/2019/47
- Views 132
- Downloads 0
ROLE OF FIBEROPTIC BRONCHOSCOPY IN SUSPECTED CASES OF LUNG CANCER
Endobronchial examination was first carried out in the last decade of nineteenth century for the purpose of removing inhaled foreign bodies, and as long as 1904 a rigid bronchoscope with provision for suction & illuminat...
TO STUDY THE RADIOLOGICAL CHANGES OF MALABSORPTION SYNDROME IN LACTOSE MALABSORBERS
BACKGROUND Lactose malabsorption is a serious issue and since malnutrition is common in our community, it was deemed worthwhile to conduct a study of lactose malabsorption in malnutrition. The problem of malnutrition in...
LEVONORGESTREL-RELEASING INTRAUTERINE SYSTEM AS AN ALTERNATIVE THERAPY IN ABNORMAL UTERINE BLEEDING
BACKGROUND Abnormal uterine bleeding is one of the most frequent reasons for gynaecological consultation, occurring in approximately 30% of women of reproductive age. Menorrhagia by definition implies a menstrual blood l...
ROAD SAFETY; HOW WELL-INFORMED ARE OUR RURAL POPULATION?
A community based cross sectional study was carried out in a rural block of north Tamilnadu to assess the knowledge; attitude and practice of general population of age group 18 to 35 regarding road safety rules. A semi s...
ASSESSMENT OF QUALITY OF LIFE IN GERIATRIC POPULATION IN THE FIELD PRACTICE AREA OF URBAN HEALTH TRAINING CENTRE, VIMSAR, BURLA
BACKGROUND Ageing is generally defined as a process of deterioration in the functional capacity of an individual that results from structural changes, with advancement of age. Ageing is a universal process and it affects...