A Study of Clinical & Biochemical Profile of Patients with Periodic Paralysis with Special Reference to Hypokalemic Periodic Paralysis
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Background: Periodic paralysis is a disorder with episodic, hyporeflexic, and short-lived skeletal muscle weakness. Patients present with repeated episodes of the weakness of the limb muscles which last for few hours to few days and are often precipitated by exercises, heavy meals or fasting. hypokalemic periodic paralysis (HPP) is a form of metabolic myopathy, which is characterized by hypokalemia, acute flaccid paralysis, potentially fatal episodes of muscle weakness and lifethreatening cardiac arrhythmias. But prompt and early recognition of this condition and initiation of treatment can lead to excellent recovery. Aim: To study the clinical & biochemical profile of patients of hypokalemic periodic paralysis and to determine the association of dietary habits (fermented rice) with HPP. Methods: The cross-sectional study design with the total 52 patients of HPP was selected in 21-60 year age group, from Pt. Jawaharlal Nehru Memorial Medical College, Department of Medicine, Raipur, C.G. (Pt. JNMMC) and associated hospital (Dr. BRAMH, Raipur, C.G.). The descriptive study was used for analyzing the data. Results: Total 52 patients were selected. The mean age of the patients was 37.98±9.18 years. Most of the subjects are male (n=42, 80.7%), taking fermented rice (bassi) in the diet (n=51, 98%), and had no precipitating event. Most of the subjects (n=50, 96.2%) had decreased tone in all 4 limbs, DTR absent (n=33, 63.46%), haemoglobin level <12gm% (n=34, 65.4%), low serum potassium level <3.5meq/l (n=42, 80.7%), and had sinus bradycardia in ECG (n=13, 25%) ). Conclusion: Limitations of the study include small sample size and lack a control group. Periodic paralysis is an episodic, short-lived and hyporeflexic skeletal muscle weakness. Most patients consumed fermented rice (bassi) on a daily basis and had hypokalemia. Patients presented with acute flaccid progressive motor paralysis should be treated with intravenous potassium regardless of low or normal serum potassium level as they responded well without any residual weakness.
Authors and Affiliations
Dr Yogendra Malhotra, Dr. Harshlata Sahu
Keywords
Related Articles
- EP ID EP434307
- DOI 10.9790/0853-1801080408.
- Views 50
- Downloads 0
Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrome; Case Report and Literature Review
Introduction: Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrome is a rare congenital absence of uterus and the upper two-thirds of the vagina in women who have normal development of secondary sexual characteristics and norm...
Assessment of lateral femoral wall thickness as a measure to predict postoperative lateral femoral wall fractures in intertrochanteric fractures treated with Dynamic Hip Screw
Background: Intertrochanteric fracture is defined as the fracture in which the main plane of bony separation passes the tip of the greater trochanter obliquely downwards and inwards to or through the lesser trochanter. I...
Antibiotic susceptibility pattern of bacterial strains isolated from children with upper respiratory tract infection
Introduction:Paediatric respiratory tract infections are among the most common reasons for attending hospital and are associated with significant morbidity and mortality. The most infections are limited to the upper resp...
Root Resorption Associated with Rapid Molar Intruder (RMI)
Introduction: Treatment of anterior open bite is based upon either intrusion of posterior teeth or extrusion of anterior teeth.Intrusion of posterior teeth might carry the risk of External root resorption (ERR). ERR is o...
A Clinico-Epidemiological Study of Erythroderma in a Tertiary Care Center in Jharkhand
Erythroderma is an inflammatory skin condition which presents with extensive erythema and scaling of skin. It may be complicated by various metabolic abnormalities and is a life threatening condition. We conducted a pros...