A Study of Clinical Profile of Multidrug Resistant Typhoid Fever In Children
Journal Title: National Journal of Integrated Research in Medicine - Year 2011, Vol 2, Issue 3
Abstract
Background: Salmonella typhi infection remains a serious problem in developing country. It has been estimated that approximately 12.5 million cases of typhoid fever occurs annually in the developing countries with 7.7 million cases in Asia alone. The disease is predominantly a disease of school age children and young adults and is reported to be a milder in infants and young children. Methods: A total of 150 children with clinical and/or laboratory diagnosis of typhoid fever admitted to the tertiary care level government hospital attached with the Government medical college in Pediatrics ward were reviewed during the months of JUNE to MAY for demographic data such as age, sex, clinical features, result of laboratory tests and antibiotic sensitivity in vivo. Results: There were 88 male and 62 female patients, from the age group ranging from 2 years to 12 years. Predominant symptoms were fever, abdominal pain , vomiting and headache. Hepatomegaly was almost twice as frequent as spleenomegaly. Common clinical signs of typhoid fever in adults such as relative bradycardia and rose spots were seldom documented in children. Fever, Toxic look, coated tongue and hepato-spleenomegaly were common clinical signs of clinical presentation in children. The positivity rate of WIDAL test and Blood Culture was 71.33% and 5.33% respectively. Hepatitis, Bronchitis and Encephalopathy were commonly observed complications of Multidrug resistant typhoid fever in this study. Antibiotics sensitivity in vivo revealed resistance rates of 78.12% for Ampicillin, 84.2% for Trimethoprim-Sulfamethoxazole (Co-trimoxazole), 19.5% for Ciprofloxacin, 14.28% for Ofloxacin and 20% for Cefotaxime. Conclusions : No resistance was detected against Cefixime and Ceftriaxone. Except the two patients died during the period of observation of this clinical study, all paediatrics patients survive from their illness completely.[ Gosai M M et al NJIRM 2011; 2(3) : 87-90].
Authors and Affiliations
Gosai Mehul. M, Hariyani Hareshwaree. B. , Purohit Payal . H. , Momin Abeda. G.
Keywords
Related Articles
- EP ID EP40152
- DOI -
- Views 372
- Downloads 0
Awareness about SuJok Therapy among medical students
Su = hand and Jok = foot. it is Korean words relating to a therapy that employs hands and feet as treatment areas for the whole body. Professor Park, Jae Woo is a Korean scientist and philosopher. Exploratory study was...
Histological Study of Adenomatous Goitre
Background & objectives: Multinodular goitre is probably the most common endocrine problem in the world today. Neither a well formulated nor a simple procedure is available for the management of MNG, hence the need for...
The Surgical Management of Diabetic Foot
Diabetes has proved itself a silent killer disease. Today in the world maximum numbers of the patients are suffering from this disease, and moreover they are passing through the associations of the complications too. I...
Serum PSA level in Prostatic lesions with Histopathological correlation in Gujarat
Background: Prostate specific antigen (PSA) has been widely used in the diagnosis and management of patients with prostate cancer. It may be elevated in other prostatic diseases and surgical procedures. PSA exists in t...
A Study of Hearing Thresholds at Speech and High Frequencies in Textile Workers
Present study was carried out on 50 textile workers (34 males and 16 females) of Kumbharwada, Bhavnagar. All were exposed to high intensity industrial noise in plastic weaving Textile industry. Other causes of Hearing...