A Study of Correlation of Disease Severity with Antibody Titers in Rheumatoid Arthritis
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 2
Abstract
ABSTRACT Introduction: Rheumatoid Arthritis (RA) is one of the most frequent autoimmune diseases in the world which affects about 1% of people. Anti-Cyclic Citrullinated Peptides (Anti-CCP) is shown to be more specific than rheumatoid factor in the diagnosis of RA. This test becomes positive in early stage of disease and it has a high predictive value. Aim: To correlate the relationship between anti-CCP antibody and rheumatoid factor titers and disease activity scores. Materials and Methods: A cross-sectional study was performed in 50 patients with RA for evaluating the relation between anti-CCP antibody titer and Disease Activity Score 28 (DAS28), Simplified Disease Activity Index (SDAI) and Clinical Disease Activity Index (CDAI). A detailed examination of each patient including their demographic characteristics, duration of disease, number of tender and swollen joints, ESR and C-reactive protein, patient’s and physician’s global assessment by VAS (0-10) and titers of rheumatoid factor and anti-CCP antibody. Patients who fulfilled the ACR-EULAR 2010 criteria were included. The statistical analysis was done using Pearson’s correlation coefficient. A p-value of less than 0.05 was considered significant. Results: Of the 50 patients which were included (mean age, 44.82 range, 18-70), 38 were females and 12 were males. Mean ESR was 54±27 mm/hr and Mean CRP was 17.277±23.41 mg/dL. Mean DAS 28 was 5.955±0.962; mean SDAI was 46.9±27.1 and CDAI 28.9±10.8. There was positive correlation (p<0.001) between DAS28 and SDAI (r=0.550) and CDAI (r=0.808). Anti-CCP level was associated with SDAI (r=0.317) and CDAI (r=0.282) (p<0.05). Conclusion: There was significant correlation in the titers of anti-CCP and disease activity indices-SDAI and CDAI. Patients with higher levels of anti-CCP antibody had greater activity.
Authors and Affiliations
Praveen Singh Madan, Amarnath Dinakar Savur, Surendra Umesh Kamath, Shrikala Baliga, Sharan Mallya
Keywords
Related Articles
- EP ID EP579837
- DOI 10.7860/JCDR/2019/34558.12558
- Views 111
- Downloads 0
Controversies in Serotonin Syndrome Diagnosis and Management: A Review
Over the past few years, Serotonin Syndrome (SS) has become a significant clinical concern. Over the last decade, United States saw a surge in antidepressant use. SS characteristically presents as the triad of altered me...
Maintaining ‘V-Contour’ of the Neck after Surgery for Neglected Congenital Muscular Torticollis in an Adult (A New Technique)
ABSTRACT In Congenital Muscular Torticollis (CMT), also called twisted neck or wryneck, an individual holds his or her head tilted to one side. There is a little consensus on the treatment approach of neglected CMT after...
Variations of Adipokines and Insulin Resistance in Primary Hypothyroidism
Introduction: Hypothyroidism is a common concern in endocrinology practice, which plays a significant role in metabolic and development processes. Obesity, hyperlipidaemia and hypertension may complicate hypothyroidism....
Histopathological Changes in Skin after Electric Current Injury: An Autopsy Study
ABSTRACT Introduction: With the proliferation of electrical equipment and devices, there is a rise in deaths due to electrocution injuries. There may be allegations of electric burns either by way of accident or torture....
Consistent Level IIa Node as a Surgical Landmark for Identification of Spinal Accessory Nerve
ABSTRACT Introduction: Treatment of Oral Squamous Cell Carcinoma (SCC) requires a composite resection of the lesion and elective/therapeutic neck dissection, whenever a surgical option is being considered as a form of tr...