A Study of Correlation of Pre-operative Serum CA-15.3 with Respect to Prognostic Factors and Early Recurrence in Breast Carcinoma in A Tertiary Care Centre in India
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 10
Abstract
Introduction: There is a huge list of prognostic markers in breast cancer but the availability of a circulating prognostic factor, which is cost effective, especially fit to provide independent data and was prognostic would be of value in breast cancer. The study was aimed to correlate serum CA 15.3 levels at the time of presentation with various other prognostic markers like tumour size, Nodal status, TNM staging, ER,PR and Her2/neu status, HPE report of tumour metastasis, early recurrence within one year and whether it can be used as a prognostic marker, indicator for tumour aggressiveness and recurrence . Material and methods: It was an institution based, prospective observational study in a tertiary care centre. Study was conducted on patients who attended the department of General Surgery at Medical College Kolkata. The Pearson correlation test was used to examine association between parametric variables and Serum CA 15.3 levels and Spearman’s Rank Correlation test was applied to check association of all nonparametric variables. Results: Serum CA 15.3 Levels correlated highly significantly with size of breast tumor, metastasis and clinical staging and significantly and with T-Stage and Nodal Status all having a positive correlation. Serum CA 15.3 Levels also correlated highly significantly with histological Grade and lymphovascular invasion and recurrence at one year with a positive correlation. Serum CA 15.3 levels however had negative correlation with age of the patient. Conclusion: CA 15.3 can be used as diagnostic and prognostic marker in the most common carcinoma i.e ductal carcinoma of breast.
Authors and Affiliations
Chandan Roy Choudhury, Neha Choudhary
Keywords
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