A study of cutaneous adverse drug reaction patterns with causality and severity assessment at a tertiary care centre
Journal Title: IP Indian Journal of Clinical and Experimental Dermatology - Year 2018, Vol 4, Issue 3
Abstract
Introduction Prescribed medications are intended to relieve sufferings during the course of illness Occasionally due to the unpredictable pharmacological nature of the drug the unique physiological condition of the patients andor due to any other factors drugs cause Adverse Drug Reactions ADRs Few of the ADRs are quite severe and if not adequately and promptly managed may lead to serious complications and even death Apart from this the high frequency of obnoxious ADRs may also drive the patients to question the reliability of the given pharmacotherapy and that may further lead to medication nonadherance Cutaneous ADRs are quite common and few of them are very severe which lead to significant comorbidities Early identification of the condition as well as the culprit drug and omitting it at earliest holds the keystone in management and prevention of a more serious reaction Thus it is necessary to have a sound monitoring and reporting of cutaneous ADRs and also an adequate analysis and interpretation of their entire pattern of the occurrenceAim To study the patterns of cutaneous adverse drug reactions with causality and severity assessment in tertiary care hospitalObjective To Identify analyse and report cutaneous ADRs and drug classes responsible for the sameMaterials and Methods A Prospective study was carried out over a period of 5 months among the outpatients and inpatients in Department of Skin and Venereal Diseases A total of 35 patients were enrolled as per selection criteria Chisquare test was applied in order to investigate whether the distribution of categorical variables differ from one anotherResult Out of 35 patients enrolled in the study 12 patients had maculopapular drug rash and the commonest causative drug was phenytoin 9 patients in the study had fixed drug reaction the commonest cause was nimesulide 4 patients were of erythema multiforme the commonest cause was NSAIDS 3 patients each of Toxic Epidermal Necrolysis and Steven Johnson syndrome There was 1 case of idiosyncratic drug toxicity due to methotrexate 1 case of Drug Reaction with Eosinophilia and Systemic Symptoms due to phenytoin 1 case of drug induced urticaria due to metronidazole and 1 case of bullous drug reactionConclusion After the cutaneous drug eruption was diagnosed and treated Patients were counselled and provided with the ADR alert card provided for emergency conditionKeywords Adverse drug reactions Cutaneous Naranjo Hartwig
Authors and Affiliations
Dhaval B Joshi, Rashmi Mahajan, Kishan Ninama, Foram Shukla, Charansakhi Panchal
Keywords
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- EP ID EP488891
- DOI 10.18231/2581-4729.2018.0041
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