A Study of Dexmedetomidine as a General Anesthetic Adjuvant in Patients Undergoing Abdominal Surgeries

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A Study of Dexmedetomidine as a General Anesthetic Adjuvant in Patients Undergoing Abdominal Surgeries

Journal Title: Saudi Journal of Medicine - Year 2018, Vol 3, Issue 5

Abstract

Abstract:Adjuvants are commonly used during general anesthesia in order to reduce the requirements of the general anesthetics. Dexmedetomidine is one of an important general anesthetic adjuvant used because of its useful properties like sedative, analgesic and anxiolytic. It has other important useful properties like cardioprotection, neuroprotection and minimal respiratory depression. We in the present study tried to evaluate the efficacy of dexmedetomidine in different concentration when used as an infusion during general anesthesia in patients undergoing routine abdominal surgeries. Methods: the study was conducted in Rajiv Gandhi Institute of Medical Sciences and Hospital [RIMS], Adilabad. The patients were selected from those undergoing abdominal surgeries. They were randomly divided into three groups. Group A (n=20) patients acting as controls received IV saline 10ml. Group B received Dexmedetomidine 0.5 µg/Kg/hr IV and Group C received Dexmedetomidine 1 µg/Kg/hr IV. Anesthesia was maintained with N2O to O2 mixture of 60:40. MAP values were maintained within 25% of the baseline values. Recovery times from tracheal extubation, modified Alderete score, VAS scores, tolerating liquids, and passage of flatus was noted. Results: The mean duration of surgery in Group A was 145.45 ± 20.06 minutes, mean duration of anesthesia was 180 ± 25 minutes. The mean duration of infusion of dexmedetomidine was 160 ± 20. For group B the values were 130.12 ± 24.75, 160.0 ± 22.0, and 140 ± 90 minutes respectively. The values for group C were 121.59 ± 18.16, 145 ± 26 and 125 ± 15minutes. The P values between group A and C were significant in Mean duration of anesthesia and mean duration of infusion. The time to suction catheter response was significantly higher in Group C. The modified Aldrete scores in Group B and Group C were found to be significant when compared to Group A similarly postoperative nausea and vomiting was significantly lesser in group C and VAS scores of pain were also significantly lesser in the Group C as compared to Group A and B. conclusion: Dexmedetomidine is low concentrations may be useful to provide sedation and mild analgesia at the same time preserving the cardiovascular and respiratory functions. Therefore dexmedetomidine when used as a general anesthetic adjuvant during routine abdominal surgeries reduces the sevoflurane and opioid requirements and results in better recovery of the patients. Keywords: Dexmedetomidine, Abdominal surgeries, Anesthetic adjuvant.

Authors and Affiliations

N. Chandra Shekar

Keywords

Dexmedetomidine Abdominal surgeries Anesthetic adjuvant.

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