A Study of Effect of Telmisartan and Telmisartan in combination with Hydrochlorthiazide on Serum Uric acid and Serum Potassium levels in patients of Essential Hypertension
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 4
Abstract
Background- The objectives of the present study were to determine and compare the changes in serum uric acid and potassium level among patients treated with telmisartan and telmisartan with hydrochlorothiazide and to measure and compare the change in blood pressure among the two groups. Methodology- Prospective cohort of patients attending outpatient and inpatient departments in General Medicine Department of People’s Hospital for a period of 18 months from November 2016 to April 2018 in the age range of 20-70 years with essential hypertension were recruited. A total of 184 patients were examined and followed up using a questionnaire. The data collected was entered and analysed in SPSS version 22.0. Results- Among 184 patients, 92 were on Group 1 (Telmisartan 40 mg (T)), 75 were on Group 2 - Telmisartan/Hydrochlorthiazide40/12.5&17 were on Group 3 - Telmisartan/Hydrochlorthiazide - 80/12.5.In group 2, at base line the mean S. Uric acid was 4.16 ± 0.97 mg/dl which on follow up rose to 4.40 ± 1.09 mg/dl. The mean elevation in S. Uric acid was 0.23 mg/dl, which is statistically significant (p>0.05) and in group 3, the mean S. Uric acid at base line 4.35 ± 0.94 mg/dl. On follow up it was 4.64 ± 1.16 mg/dl. The mean elevation in S. Uric acid was 0.29 mg/dl which is statistically significant (p<0.05). Conclusion- In Telmisartan monotherapy there was no significant change in S. Uric acid and S. potassium. Telmisartan 40 mg in combination with hydrochlorothiazide12.5mg did not show a significant change in S. potassium but there was significant increase in S. Uric acid. Telmisartan 80 mg in combination with hydrochlorothiazide 12.5mg showed a significant increase in S. Uric acid.
Authors and Affiliations
Dr Atul Patel, Dr Sushil Jindal, Dr Shaifali Bansal
Keywords
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- EP ID EP573549
- DOI 10.9790/0853-1804108492.
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