A study of effect of TXA on hemorrhagic progression of contusion of traumatic brain injury patients
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 9
Abstract
Introduction: Traumatic brain (TBI) is a leading cause of death and disability. Intracranial bleeding is a common complication of TBI, and intracranial bleeding can develop or worsen after hospital admission. Hemostatic drugs may reduce the occurrence of size of intracranial bleeds and consequently lower the morbidity and mortality associated with TBI. Worldwide, over 10 million people suffer of TBI each year.1approximately 90% of deaths occur in low- and middle-income countries. majority of patients are young adults, and many patients experience burden is considerable. With rapidly increasing motorization, the incidence is predicted to rise. Among patients with moderate or severe TBI, who are found to have intracranial bleeding on a CT scan taken soon after hospital admission, intracranial bleeding progresses in 84% of patients showing hemorrhagic progression of contusion (HPC). Aims and Objective: To study the Effect of TXA on Hemorrhagic Progression of Contusion of Traumatic Brain Injury Patients Methodology: This was case control study having two groups one is treatment TXA (Tranexamic acid), Other control group is not having TXA treatment, patients were randomly allocated in this two groups with their consent total 200 patients 100 in TXA group and 100 in control study 16 patients who received tranaexamic acid had hemorrhagic of contusion Result: In our study 16 patients who received tranaexamic acid had hemorrhagic of contusion. 46 patients from control group had hemorrhagic progression of contusion. The effect of tranaexamic acid on hemorrhagic progression of contusion was considered extremely significant. (P <0.0001, df= 1, OR =0.2236 with 95%CI)Chi-square Test: The two-sided P value is < 0.0001, considered extremely significant. There is significant effect of TXA on HPC with GCS change. Chi-square Test the two-sided P value is 0.0208, considered significant. There was not statistically significant Effect of TXA on HPC in contusion and haematoma of non-operated patients Chi-square Test: The two-sided P value is 0.7340, considered not significant. Conclusion: The larger effect on intracranial bleeding observed is consistent with the evidence of effectiveness of tranaexamic acid to reduce haemorrhagic progression of contusion. The effect is significant in contusions than in hematoma.
Authors and Affiliations
Sachin Lalasaheb Pawar
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