A study of estrogen and progesterone receptor status in breast carcinoma and its correlation with tumor grading
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2016, Vol 20, Issue 2
Abstract
Introduction: Rise in the incidence of breast cancers in India. Objective: 1. To determine the ER and PR status in unselected breast malignancy cases. 2. Correlate them with modified Bloom and Richardson grading. Material and Methods: This study comprised of 70 cases of breast carcinoma reported in a period of 4 years in the department of Pathology, Gandhi Medical College, Secunderabad. Tissue sections were stained with H and E and histological examination was done. Sections for IHC were taken onto poly-l-lysine coated slides and stained by immunoperoxidase method using ER and PR monoclonal antibodies. Results: Out of 70 cases, 87.88% were IDC (NOS) and two cases (6.06 %) of invasive lobular and mucinous each. Grade was II in 58.49% cases followed by grade III in 20.30 %in remaining 21.21% cases grade was I. Out of 70 cases, 43.42% were ER positive and 39.33% were positive for PR. Correlating with histological grade out of 15 cases of grade I, 86.67 % were positive for both ER and PR. Out of 34 cases of grade II, 44.1% were ER positive and 47.05% were PR positive and in remaining 21cases of grade III, 19.04% were found ER positive and 14.29% PR positive. Conclusion: Histological grading was significantly associated with ER and PR. Hormone receptor immunoreactivity was found to be inversely correlating with histological grade.
Authors and Affiliations
Vijaya Lakshmi K, K Rama Devi
Keywords
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