A STUDY OF FASTING INSULIN LEVELS IN NON-OBESE INDIVIDUALS WITH ESSENTIAL HYPERTENSION AND ITS COMPLICATIONS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 33
Abstract
BACKGROUND An association between essential hypertension and defective insulin secretion has been identified. To study the fasting insulin levels in non-obese, non-diabetic Hypertensive subjects. Although hyperinsulinemia, a surrogate of insulin resistance, may play a role in the pathogenesis of hypertension (HTN), the association between fasting insulin level and HTN development is still controversial. We examined the relation between fasting insulin and incidence of HTN in nonobese individuals. To correlate insulin levels with hypertension and its complications. METHODS 50 patients diagnosed to have hypertension stage I and above as per jNC - 7 report and 50 controls who are sex matched normal healthy controls. This study is conducted in Bangalore medical college Victoria hospital, Bangalore. Patients of essential hypertension of varying duration admitted to medical wards or treated at OPD department were chosen randomly for this study. All patients who are detected to have hypertension as per report of the JNC7 and are non-obese with BMI<30Kg/m2 . Two or more readings separated by 2 minutes were averaged. In newly detected hypertensive patients the diagnosis is based on the average of two or more readings taken at each of two or more visits after an initial screening. Clinical examination and appropriate investigation ruled out secondary hypertension. Fasting serum insulin levels - (normal value 2.1 to 30micro units/ml) estimated by radioimmunoassay method. RESULTS Fasting serum insulin level was significantly (p<0.001) higher in essential hypertensive male patients than normotensive subjects. Fasting serum insulin level shows significant positive correlation with systolic blood pressure in hypertensive patients. CONCLUSIONS This study reveals that essential hypertension has positive and significant relationship with fasting serum insulin level.
Authors and Affiliations
Shivanna Poorna Prasad, Gavigatt Sanket Patil
Keywords
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- EP ID EP670472
- DOI 10.18410/jebmh/2019/457
- Views 74
- Downloads 0
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