A Study of Hemodynamic Response to Intubation with Suxamethonium and Org 9426 (Rocuronium)
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 6
Abstract
Abstract: There is hemodynamic stress responses to tracheal intubation and can cause adverse cardiovascular events in patients with or without cardiovascular disease. The aim of the present study was to compare the intubating conditions and changes in heart rate and blood pressure achieved after using suxamethonium and rocuronium during intubation in patients undergoing elective surgical procedures. Methods: It is prospective randomized controlled study carried on 90 adult patients with age groups of 20-60 years of either sex. They were posted for elective surgery in Rajiv Gandhi Institute of Medical Sciences [RIMS], Adilabad. They were randomly divided into two groups of (n=45) each. Group I (R) patients received rocuronium at the dose of 0.9mg/Kg and Group II(S) patients received suxamethonium at the doses of 1.5mg/Kg. Results: The heart rates were measured at pre-operative, after the administration of muscle relaxant followed by HR at 0 min, 5 min, and 10 minutes. There was no significant difference in heart rates during all the intervals in both groups. The systolic blood pressure [SBP] preoperative values in Group I was 120.78 ± 11.74 in Group II 117.60 ± 10.12 after the administration of muscle relaxant the values in Group I were 124.82 ± 12.64 and Group II were 132.51 ± 13.77, immediately after intubation the values were group I 130.71 ± 15.37 and Group II were 138.89 ± 11.45 after 5 minutes the values were 117.22 ± 13.29 and 122.64 ± 11.73 in group I and group II respectively and at 10 minutes the values were 112.0 ± 8.86 and 117.5 ± 10.57 all the p values were found to be significant except at the preoperative time. The DBP preoperative in group I was 76.60 ± 8.85 and group II was 74.15 ± 8.81 after the administration of muscle relaxant group I 80.33 ± 11.27 and group II 84.96 ± 10.61 immediately after intubation Group I 86.60 ± 13.21 group II 89.95 ± 9.48. After 5 minutes of intubation Group I 73.96 ± 11.68 and Group II 79.35 ± 9.44 at the end of 10 minutes Group I 71.84 ± 10.18 Group II 74.17 ± 9.16 respectively. Conclusion: Rocuronium bromide is as effective as suxamethonium for rapid sequence induction it has proven to be safe and hemodynamically stable and can be considered as an alternative to suxamethonium for endotracheal intubation for patients in whom suxamethonium is contraindicated.
Authors and Affiliations
Dr. Narender Bhandari
Prevalence of Premenstrual Syndrome (PMS) including insomnia in some undergraduate medical students of Nepal
Abstract:Premenstrual Syndrome (PMS) is a common disorder in young reproductive women. It is present with specific uncomfortable and unusual symptoms that clearly begin after ovulation and generally end with the onset of...
Negative Correlation Found between Insulin Resistance and Vit D Levels in Obesity
Abstract: Vitamin D deficiency probably takes a part in the development of insulin resistance. Insulin resistance also markly affects the obese population. In this study, 123 obese persons were selected, and homeostatic...
Comparison of Vaginal vs Oral Misoprostol for Induction of Labor at Term Gestation
Abstract: To compare efficacy and safety of 50 microgram misoprostol vaginally with oral route for induction of labor at term gestation. Total 100 women with term gestation, with bishop score <= 4 with various indicatio...
Effect of Hepatitis B and C Virus in HIV Co- Infected Patients: A Fifteen Year Review
Co-infection of Human immunodeficiency virus (HIV) and hepatitis B virus (HBV) or hepatitis C virus (HCV) is the simultaneous presence of these viruses in a host. One third of HIV-infected individuals suffer from chroni...
Successful tocolysis: Does cervical dialatation affect time to delay in delivery
Infants born as a result of premature labour suffer significant morbidity and mortality. Prematurity and its prevention continue to be a major challenge for the obstetrican. Since neonatal intensive care is the most expe...