A STUDY OF INFLUENCE OF DEXMEDETOMIDINE PREMEDICATION ON CHANGES IN INTRAOCULAR PRESSURE FOLLOWING ADMINISTRATION OF SUCCINYLCHOLINE AND ENDOTRACHEAL INTUBATION
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 7
Abstract
BACKGROUND Emergency surgeries for penetrating eye trauma may be complicated by elevation in intraocular pressure (IOP) caused by succinylcholine administration and endotracheal intubation. Hence, it is critical to attenuate the rise in IOP for better outcome. This study was conducted to evaluate the effect of dexmedetomidine premedication in attenuating the rise in IOP due to succinylcholine and endotracheal intubation. MATERIALS AND METHODS This non-randomised controlled trial was conducted on 70 American Society of Anesthesiologists (ASA) grade I-II patients, aged 18-60 years undergoing non-ophthalmic surgeries under general anaesthesia (GA). The patients were divided into two groups of 35 each. Group ‘C’ (control) received 10 mL normal saline, while Group ‘D’ (study group) received dexmedetomidine (0.5 µg/kg) with normal saline added to make a total volume of 10 mL. IOP, heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were recorded before and after premedication, after induction of anaesthesia, after succinylcholine administration immediately and 5 minutes post-intubation. RESULTS Data were compared using independent student ‘t’ test and chi-square test in Statistical Package for Social Sciences (SPSS) software version 22. P-value < 0.05 was considered significant. The rise in IOP, mean HR and MAP were significantly reduced after premedication in Group ‘D.’ The incidence of side effects between the groups was not significantly different. CONCLUSION The study led to the conclusion that dexmedetomidine premedication significantly attenuates the rise in IOP in response to succinylcholine administration and endotracheal intubation without any additional side-effects and can be used in emergency ophthalmic surgeries for this purpose.
Authors and Affiliations
Payaswinee Payaswinee, Deepesh Gupta, Agarwal S. N
Keywords
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- EP ID EP399156
- DOI 10.14260/jemds/2018/188
- Views 98
- Downloads 0
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