A study of pharmacokinetic interaction of Carbamazepine with Atorvastatin in dyslipidemic rats
Journal Title: Perspectives In Medical Research - Year 2016, Vol 4, Issue 3
Abstract
Introduction: Every time a drug is administered with any other prescription medicine, OTC products, herbs or even food we expose ourselves to the risk of a potentially dangerous interaction.A drug interaction occurs when the pharmacological effects of the object drug alters the intensity of the precipitant drug. Whenever two or more drugs are taken concurrently there is a chance of an interaction among the drugs that could manifest as an increase or decrease in their effectiveness or an adverse reaction or a totally new side effect that is not seen with either drug alone. Materials and Methods :The study was done on male Sprague dawley rats, divided into 5 groups each having at least six animals.The groups were initially treated with carbamazepine at different doses for two weeks. Then all the groups were administered orally with a dose of 10 mg/kg of atorvastatin.Blood was collected from retro orbital plexus at 0, 1, 2, 4, 6,8,10 and 12 h after oral administration of atorvastatin and then subjected for analysis. Results:The influence of carbamazepine on the pharmacokinetics of atorvastatin is decrease in Cmax, bioavailability and T1/2 indyslipidemic rats. Conclusion:From the present investigation it is shown that the carbamazepine having considerable inducing effect on atorvastatin. The decreased bioavailability of atorvastatin in the study might be attributed to the induction of CYP-3A4 by carbamazepine. It might be true that, concurrent administration of the atorvastatin and carbamazepine could lead to alternations in the concentrations of either drug as both of them are substrates for CYP-3A4.
Authors and Affiliations
Raju Devde
Keywords
Related Articles
- EP ID EP300697
- DOI -
- Views 114
- Downloads 0
A Clinical Study of Fissure in Ano at Tertiary Center in North Telangana
Introduction: An anal fissure is a distressing problem faced by a patient. It is one of the commonest painful anal condition. It is relatively simple to treat with rewarding results. However, disastrous consequences can...
Nephro-protective effect ofPiliostigmathonningii extract on pregnant Wistar rats
Introduction: Pregnancy is a dynamic process characterized by dramatic physiological, anatomical and biochemical changes Aims and objectives : This research was aimed at investigating the effect of ethanol extract of P...
Study of incidence of varied etiology of first episode Pediatric Seizures and its correlation with EEG and Neuroimaging
Objective: To determine correlation between clinical features, EEG findings and neuroimaging (Magnetic Resonance Imaging) abnormalities in children with first seizure episode. Materials and Methods :It is prospective s...
Hemichorea-Hemiballismus syndrome in Ketotic hyperglycemia
Introduction: Diabetes mellitus is a common disorder in Asian people occasionally presenting with unusual manifestations such as hemichorea-hemiballismus (HC-HB) is a rare manifestation of primary diabetes mellitus. Sinc...
Gynandroblastoma - a collision tumor
Introduction: Gynandroblastoma (GA) represents an extremely rare subtype of sex-cord stromal ovarian tumor, which usually present with features of both estrogen and androgen excess depending on the type of cells in the t...