A STUDY OF PHARMACOKINETICS OF ATORVASTATIN ON TYPE 2 DIABETIC & DYSLIPIDEMIC BENGALI POPULATION OF INDIA AND BANGLADESH
Journal Title: International Journal of Medical and Clinical Research - Year 2012, Vol 3, Issue 6
Abstract
Objective: Type 2 diabetes (T2DM) is a global problem and WHO reported one million one hundred thousand deaths per year globally due to diabetes [1]. T2DM increases the mortality due to cardiovascular disease [2]. The study was designed to get an idea how the T2DM community of Bengal and Bangladesh are responding to atorvastatin, the kinetics of the improvement of lipid and diabetic status specially LDL Cholesterol (LDLC). Soybean/Sunflower oil was advised to use as a cooking medium as both the oil contains poly unsaturated fatty acid as a result would help to minimize VLDL Cholesterol (VLDLC) and triglycerides (TG). Methods: Four hundred fifty Type 2-Diabetes Mellitus (T2DM) patients of which 400 with slightly elevated lipid profile and 50 patients were T2DM with gross dyslipidaemia were considered as study material. The patients are male and in the age group of 35-50 years. The basal lipid and diabetic profile were estimated. The medication for diabetes and dyslipidaemia were started. The patients were on strict diet regime, nonsmoker, non-alcoholic and user of white oil (soybean/sunflower) as cooking medium. They were on 10mg atorvastatin per day. After 6 months and after 12 months a follow up was done to get an idea about the effect of atorvastatin on the lipid profile of the patients. Results: Both the group of patients with moderate and gross lipidemia have responded well. Even gross dyslipidemics shown improvement with 10mg atorvastatin per day. The diabetes profile and atherogenic profile were also improved. One tailed P value of 0 to 6 months and 6 to 12 months denoted significant changes. Conclusion: The group under study responded well to the diet and medicine regime. So, the population study indicates similar regime may be of help for T2DM and hyperlipidemics of Bengali population.
Authors and Affiliations
SHYAMALI PAL, SUJOY MAJUMDAR
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- EP ID EP170065
- DOI 10.9735/0976-5530.3.6.203-206
- Views 116
- Downloads 0
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