A study of polypharmacy leading to adverse drug reactions in geriatric patients at tertiary care hospital
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2018, Vol 5, Issue 2
Abstract
Polypharmacy is a common occurrence in elderly patients due to reasons like multiple comorbdiities multiple drug prescribing physicians Adverse drug reactions ADR are most frequently observed among the elderly as the responsiveness to the drugs is altered due to number of age related confinement In the present study we plan to identify the ADRs in elderly due to polypharmacyObjectives 1 To assess the rationality of prescription based on WHO criteria and Beers criteria 2 To identify the adverse drug reactions occurring in the elderly as a result of polypharmacyMaterials and Methods This prospective study was conducted in the department of General Medicine Anil Neerukonda Hospital attached to NRI Institute of Medical Sciences Sangivalasa Visakhapatnam The study period was Sep Oct for 2 months in 2016 The patient prescriptions analyzed were 30 The inclusion criteria were 65yrs of both sexes and prescribed more than 5 drugs The details of drugs collected were analyzed according to WHOINRUD indicatorsResults Study showed that polypharmacy involving hypertension associated with diabetes and respiratory disorders receiving 104 drugs per patient About 533 of the patients received more than ten drugs per day The most common medical diagnosis associated with polypharmacy was respiratory disorders with 397 and number of drugs was 10 in that group About 189 of the drugs prescribed were potentially harmful drugs according to Beers list The incidences of ADRs were 164 among the total patients majority being type 1 ADRsConclusion The polypharmacy seen in majority of elderly patients was inappropriate The average number of drugs per prescription was high 10 Many adverse drug reactions were noted according to beers list The prescription pattern for geriatric age group should be by generic name and rational prescription should be followedKeywords Adverse drug reaction Geriatric Polypharmacy
Authors and Affiliations
K. Chandra Mouli Krishna, Swathi Ratnam Regidi
Keywords
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- EP ID EP478552
- DOI 10.18231/2393-9087.2018.0021
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