A study of pulmonary functions and Alpha-1 Antitrypsin in Chronic Obstructive Pulmonary Disease
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 9
Abstract
Chronic obstructive pulmonary disease is a major cause of health care burden worldwide and the only leading cause of death that is increasing in prevalence. Reactive oxygen and nitrogen species, which are increased in smokers, may target and modify the alpha-1 antitrypsin. The aim of the present Study is to assess the pulmonary functions and Alpha-1 Antitrypsin in nonsmoker COPD and Smoker COPD patients and to find the correlation between them. 100 patients of COPD, 50 smokers (Group A) and 50 Non smokers (Group B) were included. Alpha-1 Antitrypsin was performed on ILAB-650 fully auto analyzer and Pulmonary function, FVC, FEV1, FEV1/FVC was assessed with computerized spirometry. Stastical analysis was done using GraphPad prizm 7.01 software. A1AT (group-A 149.6±21 and group-B 185.6±32.36), FVC% (group-A 70.3 ± 18.89 and group-B 88.24± 15.72), FEV1% (group-A 50.54± 16.19 and group-B 77.56 ± 13.99), FEV1/FVC % (group-A 71.64± 13.74 and group-B 71.64± 13.74 ) were significantly (p<0.001) lower in Smokers COPD patients, as compared to Non Smokers COPD Group. Keywords: Alpha-1 antitrypsin, Chronic Obstructive Pulmonary Disease (COPD), Forced Expiratory Volume (FEV), Force Vital Capacity (FVC).
Authors and Affiliations
Dr. Mittal Panchal, Dr. Purva Hathila
Keywords
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