A Study of Serious Adverse Event associated with the use of Antiproliferative Immunosuppressive Drugs (MMF) in organ transplanted Patients
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2018, Vol 6, Issue 1
Abstract
Organ transplantation by Mycophenolate mofetil (MMF) is crucial component for treatment of choice for patients suffering from End Stage of Organ Disease, But to prevent the patient life, after transplantation the foremost requirement is a well-defined immunosuppressive therapy. Mycophenolate mofetil (MMF) was first used in the early 1990s and it is a highly effective immunosuppressant drug used in the prophylaxis of organ rejection.27 MMF is a prodrug that is rapidly metabolized to its active metabolite mycophenolic acid. 324 cases were reported from literature sources. 296 cases were judged as serious and the remaining 28 cases were judged as nonserious. Thirty two cases were reported with a fatal outcome. A total of 324 cases consisting of 1116 ADRs. This study aims to identify and characterizing to Serious Adverse Event associated with Mycophenolate mofetil used to prevent graft rejection in solid organ transplant and graft-versushost disease in transplant patients.
Authors and Affiliations
Shobharam Sahu, Poonam Rishishwar, Chhaya Rathod Sah
Keywords
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